Discriminative self-representation sparse regression for neuroimaging-based alzheimer’s disease diagnosis

Xiaofeng Zhu, Heung Il Suk, Seong Whan Lee, Dinggang Shen

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


In this paper, we propose a novel feature selection method by jointly considering (1) ‘task-specific’ relations between response variables (e.g., clinical labels in this work) and neuroimaging features and (2) ‘self-representation’ relations among neuroimaging features in a sparse regression framework. Specifically, the task-specific relation is devised to learn the relative importance of features for representation of response variables by a linear combination of the input features in a supervised manner, while the self-representation relation is used to take into account the inherent information among neuroimaging features such that any feature can be represented by a weighted sum of the other features, regardless of the label information, in an unsupervised manner. By integrating these two different relations along with a group sparsity constraint, we formulate a new sparse linear regression model for class-discriminative feature selection. The selected features are used to train a support vector machine for classification. To validate the effectiveness of the proposed method, we conducted experiments on the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset; experimental results showed superiority of the proposed method over the state-of-the-art methods considered in this work.

Original languageEnglish
Pages (from-to)27-40
Number of pages14
JournalBrain Imaging and Behavior
Issue number1
Publication statusPublished - 2019 Feb 15

Bibliographical note

Publisher Copyright:
© 2017, Springer Science+Business Media New York.


  • Alzheimer’s disease (AD)
  • Feature selection
  • Joint sparse learning
  • Mild cognitive impairment (MCI)
  • Self-representation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience


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