Distinct molecular evolution of influenza H3N2 strains in the 2016/17 season and its implications for vaccine effectiveness

Jin Il Kim; Sehee Park; Hyuk Chu; Ilseob Lee; Joon Yong Bae; Kirim Yoo; Juwon Kim; Joo Yeon Lee; Namju Lee; Miseon Kim; Jun Sub Kim; Kyung Wook Hong; Kyung Ran Jun; Jeong Nyeo Lee; Kisoon Kim; Man Seong Park

doi:10.1016/j.ympev.2018.10.042

Distinct molecular evolution of influenza H3N2 strains in the 2016/17 season and its implications for vaccine effectiveness

Jin Il Kim, Sehee Park, Hyuk Chu, Ilseob Lee, Joon Yong Bae, Kirim Yoo, Juwon Kim, Joo Yeon Lee, Namju Lee, Miseon Kim, Jun Sub Kim, Kyung Wook Hong, Kyung Ran Jun, Jeong Nyeo Lee, Kisoon Kim, Man Seong Park

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Influenza virus is a respiratory pathogen that causes seasonal epidemics by resulting in a considerable number of influenza-like illness (ILI) patients. During the 2016/17 season, ILI rates increased unusually earlier and higher than previous seasons in Korea, and most viral isolates were subtyped as H3N2 strains. Notably, the hemagglutinin (HA) of most Korean H3N2 strains retained newly introduced lysine signatures in HA antigenic sites A and D, compared with that of clade 3C.2a vaccine virus, which affected antigenic distances to the standard vaccine antisera in a hemagglutination inhibition assay. The neuraminidase (NA) of Korean H3N2 strains also harbored amino acid mutations. However, neither consistent amino acid mutations nor common phylogenetic clustering patterns were observed. These suggest that Korean H3N2 strains of the 2016/17 season might be distantly related with the vaccine virus both in genotypic and phenotypic classifications, which would adversely affect vaccine effectiveness.

Original language	English
Pages (from-to)	29-34
Number of pages	6
Journal	Molecular Phylogenetics and Evolution
Volume	131
DOIs	https://doi.org/10.1016/j.ympev.2018.10.042
Publication status	Published - 2019 Feb

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

Hemagglutinin
Influenza
Molecular evolution
Neuraminidase
Vaccine effectiveness

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ympev.2018.10.042

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Kim, J. I., Park, S., Chu, H., Lee, I., Bae, J. Y., Yoo, K., Kim, J., Lee, J. Y., Lee, N., Kim, M., Kim, J. S., Hong, K. W., Jun, K. R., Lee, J. N., Kim, K., & Park, M. S. (2019). Distinct molecular evolution of influenza H3N2 strains in the 2016/17 season and its implications for vaccine effectiveness. Molecular Phylogenetics and Evolution, 131, 29-34. https://doi.org/10.1016/j.ympev.2018.10.042

Kim, JI, Park, S, Chu, H, Lee, I, Bae, JY, Yoo, K, Kim, J, Lee, JY, Lee, N, Kim, M, Kim, JS, Hong, KW, Jun, KR, Lee, JN, Kim, K & Park, MS 2019, 'Distinct molecular evolution of influenza H3N2 strains in the 2016/17 season and its implications for vaccine effectiveness', Molecular Phylogenetics and Evolution, vol. 131, pp. 29-34. https://doi.org/10.1016/j.ympev.2018.10.042

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abstract = "Influenza virus is a respiratory pathogen that causes seasonal epidemics by resulting in a considerable number of influenza-like illness (ILI) patients. During the 2016/17 season, ILI rates increased unusually earlier and higher than previous seasons in Korea, and most viral isolates were subtyped as H3N2 strains. Notably, the hemagglutinin (HA) of most Korean H3N2 strains retained newly introduced lysine signatures in HA antigenic sites A and D, compared with that of clade 3C.2a vaccine virus, which affected antigenic distances to the standard vaccine antisera in a hemagglutination inhibition assay. The neuraminidase (NA) of Korean H3N2 strains also harbored amino acid mutations. However, neither consistent amino acid mutations nor common phylogenetic clustering patterns were observed. These suggest that Korean H3N2 strains of the 2016/17 season might be distantly related with the vaccine virus both in genotypic and phenotypic classifications, which would adversely affect vaccine effectiveness.",

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author = "Kim, {Jin Il} and Sehee Park and Hyuk Chu and Ilseob Lee and Bae, {Joon Yong} and Kirim Yoo and Juwon Kim and Lee, {Joo Yeon} and Namju Lee and Miseon Kim and Kim, {Jun Sub} and Hong, {Kyung Wook} and Jun, {Kyung Ran} and Lee, {Jeong Nyeo} and Kisoon Kim and Park, {Man Seong}",

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doi = "10.1016/j.ympev.2018.10.042",

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AU - Kim, Jin Il

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AU - Bae, Joon Yong

AU - Yoo, Kirim

AU - Kim, Juwon

AU - Lee, Joo Yeon

AU - Lee, Namju

AU - Kim, Miseon

AU - Kim, Jun Sub

AU - Hong, Kyung Wook

AU - Jun, Kyung Ran

AU - Lee, Jeong Nyeo

AU - Kim, Kisoon

AU - Park, Man Seong

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N2 - Influenza virus is a respiratory pathogen that causes seasonal epidemics by resulting in a considerable number of influenza-like illness (ILI) patients. During the 2016/17 season, ILI rates increased unusually earlier and higher than previous seasons in Korea, and most viral isolates were subtyped as H3N2 strains. Notably, the hemagglutinin (HA) of most Korean H3N2 strains retained newly introduced lysine signatures in HA antigenic sites A and D, compared with that of clade 3C.2a vaccine virus, which affected antigenic distances to the standard vaccine antisera in a hemagglutination inhibition assay. The neuraminidase (NA) of Korean H3N2 strains also harbored amino acid mutations. However, neither consistent amino acid mutations nor common phylogenetic clustering patterns were observed. These suggest that Korean H3N2 strains of the 2016/17 season might be distantly related with the vaccine virus both in genotypic and phenotypic classifications, which would adversely affect vaccine effectiveness.

AB - Influenza virus is a respiratory pathogen that causes seasonal epidemics by resulting in a considerable number of influenza-like illness (ILI) patients. During the 2016/17 season, ILI rates increased unusually earlier and higher than previous seasons in Korea, and most viral isolates were subtyped as H3N2 strains. Notably, the hemagglutinin (HA) of most Korean H3N2 strains retained newly introduced lysine signatures in HA antigenic sites A and D, compared with that of clade 3C.2a vaccine virus, which affected antigenic distances to the standard vaccine antisera in a hemagglutination inhibition assay. The neuraminidase (NA) of Korean H3N2 strains also harbored amino acid mutations. However, neither consistent amino acid mutations nor common phylogenetic clustering patterns were observed. These suggest that Korean H3N2 strains of the 2016/17 season might be distantly related with the vaccine virus both in genotypic and phenotypic classifications, which would adversely affect vaccine effectiveness.

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Distinct molecular evolution of influenza H3N2 strains in the 2016/17 season and its implications for vaccine effectiveness

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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