Distinctive Mediating Effects of Subcortical Structure Changes on the Relationships Between Amyloid or Vascular Changes and Cognitive Decline

Na Yeon Jung, Jeong Hyeon Shin, Hee Jin Kim, Hyemin Jang, Seung Hwan Moon, Seung Joo Kim, Yeshin Kim, Soo Hyun Cho, Ko Woon Kim, Jun Pyo Kim, Young Hee Jung, Sung Tae Kim, Eun Joo Kim, Duk L. Na, Jacob W. Vogel, Sangjin Lee, Joon Kyung Seong, Sang Won Seo

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: We investigated the mediation effects of subcortical volume change in the relationship of amyloid beta (Aβ) and lacune with cognitive function in patients with mild cognitive impairment (MCI). Methods: We prospectively recruited 101 patients with MCI who were followed up with neuropsychological tests, MRI, or Pittsburgh compound B (PiB) PET for 3 years. The mediation effect of subcortical structure on the association of PiB or lacunes with cognitive function was analyzed using mixed effects models. Results: Volume changes in the amygdala and hippocampus partially mediated the effect of PiB changes on memory function (direct effect = −0.168/−0.175, indirect effect = −0.081/−0.077 for amygdala/hippocampus) and completely mediated the effect of PiB changes on clinical dementia rating scale sum of the box (CDR-SOB) (indirect effect = 0.082/0.116 for amygdala/hippocampus). Volume changes in the thalamus completely mediated the effect of lacune on memory, frontal executive functions, and CDR-SOB (indirect effect = −0.037, −0.056, and 0.047, respectively). Conclusions: Our findings provide a better understanding of the distinct role of subcortical structures in the mediation of the relationships of amyloid or vascular changes with a decline in specific cognitive domains.

Original languageEnglish
Article number762251
JournalFrontiers in Neurology
Volume12
DOIs
Publication statusPublished - 2021 Dec 7

Bibliographical note

Funding Information:
grant funded by the Korea government (MSIT) (No.2021-0-02068, Artificial Intelligence Innovation Hub); a 2021 research grant from Pusan National University Yangsan Hospital; Brain Research Program through the National Research Foundation of

Funding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare and Ministry of Science and ICT, Republic of Korea (Grant Number: HU20C0111); a fund (2021-ER1006-00) by Research of Korea Disease Control and Prevention Agency; the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2019R1A5A2027340); Institute of Information & communications Technology Planning & Evaluation (IITP)

Publisher Copyright:
Copyright © 2021 Jung, Shin, Kim, Jang, Moon, Kim, Kim, Cho, Kim, Kim, Jung, Kim, Kim, Na, Vogel, Lee, Seong and Seo.

Keywords

  • amyloid
  • cognition
  • lacune
  • mediation
  • subcortical structure

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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