Distinctive Mediating Effects of Subcortical Structure Changes on the Relationships Between Amyloid or Vascular Changes and Cognitive Decline

Na Yeon Jung; Jeong Hyeon Shin; Hee Jin Kim; Hyemin Jang; Seung Hwan Moon; Seung Joo Kim; Yeshin Kim; Soo Hyun Cho; Ko Woon Kim; Jun Pyo Kim; Young Hee Jung; Sung Tae Kim; Eun Joo Kim; Duk L. Na; Jacob W. Vogel; Sangjin Lee; Joon Kyung Seong; Sang Won Seo

doi:10.3389/fneur.2021.762251

Distinctive Mediating Effects of Subcortical Structure Changes on the Relationships Between Amyloid or Vascular Changes and Cognitive Decline

Na Yeon Jung
, Jeong Hyeon Shin
, Hee Jin Kim
, Hyemin Jang
, Seung Hwan Moon
, Seung Joo Kim
, Yeshin Kim
, Soo Hyun Cho
, Ko Woon Kim
, Jun Pyo Kim
, Young Hee Jung
, Sung Tae Kim
, Eun Joo Kim
, Duk L. Na
, Jacob W. Vogel
, Sangjin Lee
, Joon Kyung Seong^*
, Sang Won Seo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Objective: We investigated the mediation effects of subcortical volume change in the relationship of amyloid beta (Aβ) and lacune with cognitive function in patients with mild cognitive impairment (MCI). Methods: We prospectively recruited 101 patients with MCI who were followed up with neuropsychological tests, MRI, or Pittsburgh compound B (PiB) PET for 3 years. The mediation effect of subcortical structure on the association of PiB or lacunes with cognitive function was analyzed using mixed effects models. Results: Volume changes in the amygdala and hippocampus partially mediated the effect of PiB changes on memory function (direct effect = −0.168/−0.175, indirect effect = −0.081/−0.077 for amygdala/hippocampus) and completely mediated the effect of PiB changes on clinical dementia rating scale sum of the box (CDR-SOB) (indirect effect = 0.082/0.116 for amygdala/hippocampus). Volume changes in the thalamus completely mediated the effect of lacune on memory, frontal executive functions, and CDR-SOB (indirect effect = −0.037, −0.056, and 0.047, respectively). Conclusions: Our findings provide a better understanding of the distinct role of subcortical structures in the mediation of the relationships of amyloid or vascular changes with a decline in specific cognitive domains.

Original language	English
Article number	762251
Journal	Frontiers in Neurology
Volume	12
DOIs	https://doi.org/10.3389/fneur.2021.762251
Publication status	Published - 2021 Dec 7

Bibliographical note

Funding Information:
grant funded by the Korea government (MSIT) (No.2021-0-02068, Artificial Intelligence Innovation Hub); a 2021 research grant from Pusan National University Yangsan Hospital; Brain Research Program through the National Research Foundation of

Funding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare and Ministry of Science and ICT, Republic of Korea (Grant Number: HU20C0111); a fund (2021-ER1006-00) by Research of Korea Disease Control and Prevention Agency; the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2019R1A5A2027340); Institute of Information & communications Technology Planning & Evaluation (IITP)

Publisher Copyright:
Copyright © 2021 Jung, Shin, Kim, Jang, Moon, Kim, Kim, Cho, Kim, Kim, Jung, Kim, Kim, Na, Vogel, Lee, Seong and Seo.

Keywords

amyloid
cognition
lacune
mediation
subcortical structure

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.3389/fneur.2021.762251

Cite this

Jung, N. Y., Shin, J. H., Kim, H. J., Jang, H., Moon, S. H., Kim, S. J., Kim, Y., Cho, S. H., Kim, K. W., Kim, J. P., Jung, Y. H., Kim, S. T., Kim, E. J., Na, D. L., Vogel, J. W., Lee, S., Seong, J. K., & Seo, S. W. (2021). Distinctive Mediating Effects of Subcortical Structure Changes on the Relationships Between Amyloid or Vascular Changes and Cognitive Decline. Frontiers in Neurology, 12, Article 762251. https://doi.org/10.3389/fneur.2021.762251

Jung, NY, Shin, JH, Kim, HJ, Jang, H, Moon, SH, Kim, SJ, Kim, Y, Cho, SH, Kim, KW, Kim, JP, Jung, YH, Kim, ST, Kim, EJ, Na, DL, Vogel, JW, Lee, S, Seong, JK & Seo, SW 2021, 'Distinctive Mediating Effects of Subcortical Structure Changes on the Relationships Between Amyloid or Vascular Changes and Cognitive Decline', Frontiers in Neurology, vol. 12, 762251. https://doi.org/10.3389/fneur.2021.762251

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title = "Distinctive Mediating Effects of Subcortical Structure Changes on the Relationships Between Amyloid or Vascular Changes and Cognitive Decline",

abstract = "Objective: We investigated the mediation effects of subcortical volume change in the relationship of amyloid beta (Aβ) and lacune with cognitive function in patients with mild cognitive impairment (MCI). Methods: We prospectively recruited 101 patients with MCI who were followed up with neuropsychological tests, MRI, or Pittsburgh compound B (PiB) PET for 3 years. The mediation effect of subcortical structure on the association of PiB or lacunes with cognitive function was analyzed using mixed effects models. Results: Volume changes in the amygdala and hippocampus partially mediated the effect of PiB changes on memory function (direct effect = −0.168/−0.175, indirect effect = −0.081/−0.077 for amygdala/hippocampus) and completely mediated the effect of PiB changes on clinical dementia rating scale sum of the box (CDR-SOB) (indirect effect = 0.082/0.116 for amygdala/hippocampus). Volume changes in the thalamus completely mediated the effect of lacune on memory, frontal executive functions, and CDR-SOB (indirect effect = −0.037, −0.056, and 0.047, respectively). Conclusions: Our findings provide a better understanding of the distinct role of subcortical structures in the mediation of the relationships of amyloid or vascular changes with a decline in specific cognitive domains.",

keywords = "amyloid, cognition, lacune, mediation, subcortical structure",

author = "Jung, \{Na Yeon\} and Shin, \{Jeong Hyeon\} and Kim, \{Hee Jin\} and Hyemin Jang and Moon, \{Seung Hwan\} and Kim, \{Seung Joo\} and Yeshin Kim and Cho, \{Soo Hyun\} and Kim, \{Ko Woon\} and Kim, \{Jun Pyo\} and Jung, \{Young Hee\} and Kim, \{Sung Tae\} and Kim, \{Eun Joo\} and Na, \{Duk L.\} and Vogel, \{Jacob W.\} and Sangjin Lee and Seong, \{Joon Kyung\} and Seo, \{Sang Won\}",

note = "Funding Information: grant funded by the Korea government (MSIT) (No.2021-0-02068, Artificial Intelligence Innovation Hub); a 2021 research grant from Pusan National University Yangsan Hospital; Brain Research Program through the National Research Foundation of Funding Information: This research was supported by a grant of the Korea Health Technology R\&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare and Ministry of Science and ICT, Republic of Korea (Grant Number: HU20C0111); a fund (2021-ER1006-00) by Research of Korea Disease Control and Prevention Agency; the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2019R1A5A2027340); Institute of Information \& communications Technology Planning \& Evaluation (IITP) Publisher Copyright: Copyright {\textcopyright} 2021 Jung, Shin, Kim, Jang, Moon, Kim, Kim, Cho, Kim, Kim, Jung, Kim, Kim, Na, Vogel, Lee, Seong and Seo.",

year = "2021",

month = dec,

day = "7",

doi = "10.3389/fneur.2021.762251",

language = "English",

volume = "12",

journal = "Frontiers in Neurology",

issn = "1664-2295",

publisher = "Frontiers Media SA",

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TY - JOUR

T1 - Distinctive Mediating Effects of Subcortical Structure Changes on the Relationships Between Amyloid or Vascular Changes and Cognitive Decline

AU - Jung, Na Yeon

AU - Shin, Jeong Hyeon

AU - Kim, Hee Jin

AU - Jang, Hyemin

AU - Moon, Seung Hwan

AU - Kim, Seung Joo

AU - Kim, Yeshin

AU - Cho, Soo Hyun

AU - Kim, Ko Woon

AU - Kim, Jun Pyo

AU - Jung, Young Hee

AU - Kim, Sung Tae

AU - Kim, Eun Joo

AU - Na, Duk L.

AU - Vogel, Jacob W.

AU - Lee, Sangjin

AU - Seong, Joon Kyung

AU - Seo, Sang Won

N1 - Funding Information: grant funded by the Korea government (MSIT) (No.2021-0-02068, Artificial Intelligence Innovation Hub); a 2021 research grant from Pusan National University Yangsan Hospital; Brain Research Program through the National Research Foundation of Funding Information: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare and Ministry of Science and ICT, Republic of Korea (Grant Number: HU20C0111); a fund (2021-ER1006-00) by Research of Korea Disease Control and Prevention Agency; the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2019R1A5A2027340); Institute of Information & communications Technology Planning & Evaluation (IITP) Publisher Copyright: Copyright © 2021 Jung, Shin, Kim, Jang, Moon, Kim, Kim, Cho, Kim, Kim, Jung, Kim, Kim, Na, Vogel, Lee, Seong and Seo.

PY - 2021/12/7

Y1 - 2021/12/7

N2 - Objective: We investigated the mediation effects of subcortical volume change in the relationship of amyloid beta (Aβ) and lacune with cognitive function in patients with mild cognitive impairment (MCI). Methods: We prospectively recruited 101 patients with MCI who were followed up with neuropsychological tests, MRI, or Pittsburgh compound B (PiB) PET for 3 years. The mediation effect of subcortical structure on the association of PiB or lacunes with cognitive function was analyzed using mixed effects models. Results: Volume changes in the amygdala and hippocampus partially mediated the effect of PiB changes on memory function (direct effect = −0.168/−0.175, indirect effect = −0.081/−0.077 for amygdala/hippocampus) and completely mediated the effect of PiB changes on clinical dementia rating scale sum of the box (CDR-SOB) (indirect effect = 0.082/0.116 for amygdala/hippocampus). Volume changes in the thalamus completely mediated the effect of lacune on memory, frontal executive functions, and CDR-SOB (indirect effect = −0.037, −0.056, and 0.047, respectively). Conclusions: Our findings provide a better understanding of the distinct role of subcortical structures in the mediation of the relationships of amyloid or vascular changes with a decline in specific cognitive domains.

AB - Objective: We investigated the mediation effects of subcortical volume change in the relationship of amyloid beta (Aβ) and lacune with cognitive function in patients with mild cognitive impairment (MCI). Methods: We prospectively recruited 101 patients with MCI who were followed up with neuropsychological tests, MRI, or Pittsburgh compound B (PiB) PET for 3 years. The mediation effect of subcortical structure on the association of PiB or lacunes with cognitive function was analyzed using mixed effects models. Results: Volume changes in the amygdala and hippocampus partially mediated the effect of PiB changes on memory function (direct effect = −0.168/−0.175, indirect effect = −0.081/−0.077 for amygdala/hippocampus) and completely mediated the effect of PiB changes on clinical dementia rating scale sum of the box (CDR-SOB) (indirect effect = 0.082/0.116 for amygdala/hippocampus). Volume changes in the thalamus completely mediated the effect of lacune on memory, frontal executive functions, and CDR-SOB (indirect effect = −0.037, −0.056, and 0.047, respectively). Conclusions: Our findings provide a better understanding of the distinct role of subcortical structures in the mediation of the relationships of amyloid or vascular changes with a decline in specific cognitive domains.

KW - amyloid

KW - cognition

KW - lacune

KW - mediation

KW - subcortical structure

UR - https://www.scopus.com/pages/publications/85121742712

U2 - 10.3389/fneur.2021.762251

DO - 10.3389/fneur.2021.762251

M3 - Article

AN - SCOPUS:85121742712

SN - 1664-2295

VL - 12

JO - Frontiers in Neurology

JF - Frontiers in Neurology

M1 - 762251

ER -

Distinctive Mediating Effects of Subcortical Structure Changes on the Relationships Between Amyloid or Vascular Changes and Cognitive Decline

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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