Distribution of ESBLs, AmpC β-lactamases and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal and urinary tract infections in the Asia-Pacific region during 2008-14: Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART)

SMART Asia-Pacific Group

doi:10.1093/jac/dkw398

Distribution of ESBLs, AmpC β-lactamases and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal and urinary tract infections in the Asia-Pacific region during 2008-14: Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART)

SMART Asia-Pacific Group

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Abstract

Objectives: To investigate the antimicrobial resistance and assess the molecular characteristics of β-lactamases (ESBLs, AmpC β-lactamases and carbapenemases) among Enterobacteriaceae isolates that caused intraabdominal infections (IAIs) in patients hospitalized in the Asia-Pacific region during 2008-14. Methods: Multiplex PCR was used to detect the specific types of β-lactamase in 2893 isolates with MICs of ertapenem.0.5 mg/L. In-hospital acquisition times for most isolates were also delineated. Results: Among 2728 (94.3%) isolates proven with β-lactamase production, the rates of non-susceptibility to imipenem were low (average=7.9%) among IAI Enterobacteriaceae isolates from all Asia-Pacific countries except Vietnam (17.7%) and the Philippines (10.2%). A stepwise and significant increase in annual rates of carbapenemase production among these isolates was noted. CTX-M-15 and CTX-M-14 were the dominant ESBL variants in most IAI Enterobacteriaceae species. The most abundant AmpC β-lactamase variants were bla_CMY-2 among isolates of Escherichia coli and bla_DHA-1 among isolates of Klebsiella pneumoniae. In addition, the IAI Enterobacteriaceae isolates harbouring a bla_CMY-2 or bla_DHA-1 allele were associated with high communityacquired rates (38.0% and 42.6%, respectively). AmpC ACT and MIR variants were mostly detected in Enterobacter species. The bla_NDM-1,4,5,7-harbouring isolates of E. coli, K. pneumoniae and Enterobacter cloacae were most commonly identified among IAI isolates from Vietnam and the Philippines. Also of note, bla_OXA-48- harbouring IAI Enterobacteriaceae isolates were detected exclusively in Vietnam. Conclusions: The high resistance burden in Vietnam and the Philippines warrants aggressive control policies to combat the worsening trend in antimicrobial resistance among Enterobacteriaceae species causing IAIs.

Original language	English
Pages (from-to)	166-171
Number of pages	6
Journal	Journal of Antimicrobial Chemotherapy
Volume	72
Issue number	1
DOIs	https://doi.org/10.1093/jac/dkw398
Publication status	Published - 2017 Jan

Bibliographical note

Publisher Copyright:
© The Author 2016.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Microbiology (medical)
Pharmacology (medical)
Infectious Diseases
Pharmacology

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SMART Asia-Pacific Group (2017). Distribution of ESBLs, AmpC β-lactamases and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal and urinary tract infections in the Asia-Pacific region during 2008-14: Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART). Journal of Antimicrobial Chemotherapy, 72(1), 166-171. https://doi.org/10.1093/jac/dkw398

Distribution of ESBLs, AmpC β-lactamases and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal and urinary tract infections in the Asia-Pacific region during 2008-14: Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART). / SMART Asia-Pacific Group.
In: Journal of Antimicrobial Chemotherapy, Vol. 72, No. 1, 01.2017, p. 166-171.

Research output: Contribution to journal › Article › peer-review

SMART Asia-Pacific Group 2017, 'Distribution of ESBLs, AmpC β-lactamases and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal and urinary tract infections in the Asia-Pacific region during 2008-14: Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART)', Journal of Antimicrobial Chemotherapy, vol. 72, no. 1, pp. 166-171. https://doi.org/10.1093/jac/dkw398

SMART Asia-Pacific Group. Distribution of ESBLs, AmpC β-lactamases and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal and urinary tract infections in the Asia-Pacific region during 2008-14: Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART). Journal of Antimicrobial Chemotherapy. 2017 Jan;72(1):166-171. doi: 10.1093/jac/dkw398

SMART Asia-Pacific Group. / Distribution of ESBLs, AmpC β-lactamases and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal and urinary tract infections in the Asia-Pacific region during 2008-14 : Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART). In: Journal of Antimicrobial Chemotherapy. 2017 ; Vol. 72, No. 1. pp. 166-171.

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title = "Distribution of ESBLs, AmpC β-lactamases and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal and urinary tract infections in the Asia-Pacific region during 2008-14: Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART)",

abstract = "Objectives: To investigate the antimicrobial resistance and assess the molecular characteristics of β-lactamases (ESBLs, AmpC β-lactamases and carbapenemases) among Enterobacteriaceae isolates that caused intraabdominal infections (IAIs) in patients hospitalized in the Asia-Pacific region during 2008-14. Methods: Multiplex PCR was used to detect the specific types of β-lactamase in 2893 isolates with MICs of ertapenem.0.5 mg/L. In-hospital acquisition times for most isolates were also delineated. Results: Among 2728 (94.3\%) isolates proven with β-lactamase production, the rates of non-susceptibility to imipenem were low (average=7.9\%) among IAI Enterobacteriaceae isolates from all Asia-Pacific countries except Vietnam (17.7\%) and the Philippines (10.2\%). A stepwise and significant increase in annual rates of carbapenemase production among these isolates was noted. CTX-M-15 and CTX-M-14 were the dominant ESBL variants in most IAI Enterobacteriaceae species. The most abundant AmpC β-lactamase variants were blaCMY-2 among isolates of Escherichia coli and blaDHA-1 among isolates of Klebsiella pneumoniae. In addition, the IAI Enterobacteriaceae isolates harbouring a blaCMY-2 or blaDHA-1 allele were associated with high communityacquired rates (38.0\% and 42.6\%, respectively). AmpC ACT and MIR variants were mostly detected in Enterobacter species. The blaNDM-1,4,5,7-harbouring isolates of E. coli, K. pneumoniae and Enterobacter cloacae were most commonly identified among IAI isolates from Vietnam and the Philippines. Also of note, blaOXA-48- harbouring IAI Enterobacteriaceae isolates were detected exclusively in Vietnam. Conclusions: The high resistance burden in Vietnam and the Philippines warrants aggressive control policies to combat the worsening trend in antimicrobial resistance among Enterobacteriaceae species causing IAIs.",

author = "\{SMART Asia-Pacific Group\} and Jean, \{Shio Shin\} and Hsueh, \{Po Ren\} and Tony Korman and Justin Ellem and Narelle George and Geoffrey Coombs and Thomas Ling and Owen Tsang and V. Balaji and Hiroshige Mikamo and Shinya Kusachi and Tetsu Mizutani and Kim, \{Min Ja\} and Bae, \{In Gyu\} and Umur, \{Nurulhuda Binti\} and Rajasekaram, \{Datin Ganeswrie\} and Susan Taylor and Sally Roberts and \{van der Werff\}, Koen and Dragana Drinkovic and Evelina Lagamayo and Myrna Mendoza and Tan, \{Thean Yen\} and Prabha Krishnan and Ellie Wang and Lu, \{Po Liang\} and Liu, \{Chun Eng\} and Chuang, \{Kenneth Yin Ching\} and Yu, \{Kwok Woon\} and Chen, \{Yao Shen\} and Lu, \{Min Chi\} and Siripen Panthuwong and Pattarachai Kiratisin and Phoung, \{Nguyen Tran My\} and Phuong, \{Doan Mai\} and Van, \{Nguyen Thi\} and Nga, \{Tran Thi Thanh\}",

note = "Publisher Copyright: {\textcopyright} The Author 2016.",

year = "2017",

month = jan,

doi = "10.1093/jac/dkw398",

language = "English",

volume = "72",

pages = "166--171",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Distribution of ESBLs, AmpC β-lactamases and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal and urinary tract infections in the Asia-Pacific region during 2008-14

T2 - Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART)

AU - SMART Asia-Pacific Group

AU - Jean, Shio Shin

AU - Hsueh, Po Ren

AU - Korman, Tony

AU - Ellem, Justin

AU - George, Narelle

AU - Coombs, Geoffrey

AU - Ling, Thomas

AU - Tsang, Owen

AU - Balaji, V.

AU - Mikamo, Hiroshige

AU - Kusachi, Shinya

AU - Mizutani, Tetsu

AU - Kim, Min Ja

AU - Bae, In Gyu

AU - Umur, Nurulhuda Binti

AU - Rajasekaram, Datin Ganeswrie

AU - Taylor, Susan

AU - Roberts, Sally

AU - van der Werff, Koen

AU - Drinkovic, Dragana

AU - Lagamayo, Evelina

AU - Mendoza, Myrna

AU - Tan, Thean Yen

AU - Krishnan, Prabha

AU - Wang, Ellie

AU - Lu, Po Liang

AU - Liu, Chun Eng

AU - Chuang, Kenneth Yin Ching

AU - Yu, Kwok Woon

AU - Chen, Yao Shen

AU - Lu, Min Chi

AU - Panthuwong, Siripen

AU - Kiratisin, Pattarachai

AU - Phoung, Nguyen Tran My

AU - Phuong, Doan Mai

AU - Van, Nguyen Thi

AU - Nga, Tran Thi Thanh

PY - 2017/1

Y1 - 2017/1

N2 - Objectives: To investigate the antimicrobial resistance and assess the molecular characteristics of β-lactamases (ESBLs, AmpC β-lactamases and carbapenemases) among Enterobacteriaceae isolates that caused intraabdominal infections (IAIs) in patients hospitalized in the Asia-Pacific region during 2008-14. Methods: Multiplex PCR was used to detect the specific types of β-lactamase in 2893 isolates with MICs of ertapenem.0.5 mg/L. In-hospital acquisition times for most isolates were also delineated. Results: Among 2728 (94.3%) isolates proven with β-lactamase production, the rates of non-susceptibility to imipenem were low (average=7.9%) among IAI Enterobacteriaceae isolates from all Asia-Pacific countries except Vietnam (17.7%) and the Philippines (10.2%). A stepwise and significant increase in annual rates of carbapenemase production among these isolates was noted. CTX-M-15 and CTX-M-14 were the dominant ESBL variants in most IAI Enterobacteriaceae species. The most abundant AmpC β-lactamase variants were blaCMY-2 among isolates of Escherichia coli and blaDHA-1 among isolates of Klebsiella pneumoniae. In addition, the IAI Enterobacteriaceae isolates harbouring a blaCMY-2 or blaDHA-1 allele were associated with high communityacquired rates (38.0% and 42.6%, respectively). AmpC ACT and MIR variants were mostly detected in Enterobacter species. The blaNDM-1,4,5,7-harbouring isolates of E. coli, K. pneumoniae and Enterobacter cloacae were most commonly identified among IAI isolates from Vietnam and the Philippines. Also of note, blaOXA-48- harbouring IAI Enterobacteriaceae isolates were detected exclusively in Vietnam. Conclusions: The high resistance burden in Vietnam and the Philippines warrants aggressive control policies to combat the worsening trend in antimicrobial resistance among Enterobacteriaceae species causing IAIs.

AB - Objectives: To investigate the antimicrobial resistance and assess the molecular characteristics of β-lactamases (ESBLs, AmpC β-lactamases and carbapenemases) among Enterobacteriaceae isolates that caused intraabdominal infections (IAIs) in patients hospitalized in the Asia-Pacific region during 2008-14. Methods: Multiplex PCR was used to detect the specific types of β-lactamase in 2893 isolates with MICs of ertapenem.0.5 mg/L. In-hospital acquisition times for most isolates were also delineated. Results: Among 2728 (94.3%) isolates proven with β-lactamase production, the rates of non-susceptibility to imipenem were low (average=7.9%) among IAI Enterobacteriaceae isolates from all Asia-Pacific countries except Vietnam (17.7%) and the Philippines (10.2%). A stepwise and significant increase in annual rates of carbapenemase production among these isolates was noted. CTX-M-15 and CTX-M-14 were the dominant ESBL variants in most IAI Enterobacteriaceae species. The most abundant AmpC β-lactamase variants were blaCMY-2 among isolates of Escherichia coli and blaDHA-1 among isolates of Klebsiella pneumoniae. In addition, the IAI Enterobacteriaceae isolates harbouring a blaCMY-2 or blaDHA-1 allele were associated with high communityacquired rates (38.0% and 42.6%, respectively). AmpC ACT and MIR variants were mostly detected in Enterobacter species. The blaNDM-1,4,5,7-harbouring isolates of E. coli, K. pneumoniae and Enterobacter cloacae were most commonly identified among IAI isolates from Vietnam and the Philippines. Also of note, blaOXA-48- harbouring IAI Enterobacteriaceae isolates were detected exclusively in Vietnam. Conclusions: The high resistance burden in Vietnam and the Philippines warrants aggressive control policies to combat the worsening trend in antimicrobial resistance among Enterobacteriaceae species causing IAIs.

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U2 - 10.1093/jac/dkw398

DO - 10.1093/jac/dkw398

M3 - Article

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AN - SCOPUS:85014571133

SN - 0305-7453

VL - 72

SP - 166

EP - 171

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 1

ER -

Distribution of ESBLs, AmpC β-lactamases and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal and urinary tract infections in the Asia-Pacific region during 2008-14: Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART)

Abstract

Bibliographical note

UN SDGs

ASJC Scopus subject areas

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