Distributional characteristics of lymphatic vessels in normal human nasal mucosa and sinus mucosa

Tae Hoon Kim, Sang Hag Lee, Joon Hwan Moon, Heung Man Lee, Seung Hoon Lee, Hak Hyun Jung

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


An immunohistochemical staining technique with the D2-40 antibody was undertaken to examine the functional and morphological features of lymphatic networks in tissue sections and whole-mount preparations of normal nasal mucosa and ethmoid sinus mucosa. In normal nasal mucosa, most lymphatic vessels were found in the superficial mucosa beneath the epithelial layer. Some of these vessels were dilated, whereas others were compressed and had a slit-like lumen. Whole-mount preparations revealed the extent of lymphatic vessels in normal ethmoid sinus mucosa. A network of lymphatic vessels was mainly found in the subepithelial layer, where lymphatic vessels represented rich networks, possessing antler-like branches and typical blind ends. However, these lymphatic networks were not arranged in the form of lymphangion chains, with each lymphangion consisting of a contractile compartment and valve. Thus, recognition of the distinctive features of the lymphatic network in normal nasal and sinus mucosa might aid investigations of lymphatic involvement in sinonasal diseases, such as rhinitis, sinusitis, and malignancy.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalCell and Tissue Research
Issue number3
Publication statusPublished - 2007 Mar

Bibliographical note

Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research from the Communication Disorders Center, Korea University, Korea. T.H.Kim.S.H.Lee(*).H.M.Lee.S.H.Lee.H.H.Jung Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea University, 126-1, 5 Ka, Anam-Dong, SungBuk-Ku, Seoul 136-705, South Korea e-mail: sanghag@kumc.or.kr


  • D2-40
  • Ethmoid sinus mucosa
  • Human
  • Lymphatic vessels
  • Normal nasal mucosa
  • Whole-mount preparation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology


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