Diterpenoids and Diacetylenes from the Roots of Aralia cordata with Inhibitory Effects on Nitric Oxide Production

Jun Gu Kim, Jin Woo Lee, Thi Phuong Linh Le, Jae Sang Han, Haeun Kwon, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Bioactivity-guided isolation of a MeOH extract of Aralia cordata led to the isolation of four new ent-pimarane diterpenoids (1-4) and a diacetylene (5) together with 21 known compounds (6-26). Their structures were established based on the interpretation of one- and two-dimensional NMR and HRESIMS data. The absolute configurations of the new isolates were determined by electronic circular dichroism data analysis, single crystal X-ray diffraction, and Mosher's esterification method. All compounds exhibited inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC50 values ranging from 1.1 to 69.4 μM.

Original languageEnglish
Pages (from-to)230-238
Number of pages9
JournalJournal of Natural Products
Volume84
Issue number2
DOIs
Publication statusPublished - 2021 Feb 26

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MIST) (No. 2020R1A2C1008406), the Medical Research Center Program (MRC, 2017R1A5A2015541) through the National Research Foundation of Korea, and by the Korea Basic Science Institute under the R&D program (Project No. C030440) supervised by the Ministry of Science and ICT.

Publisher Copyright:
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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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