Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha

Wenpei Liu, Ziteng Song, Huimei Wang, Xueyuan Yang, Elizabeth Joubert, Jie Zhang, Shen Li, Muhetaer Tuerhong, Munira Abudukeremu, Jin Jin, Jing Xu, Dongho Lee, Yuanqiang Guo

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


A phytochemical survey to obtain bioactive natural products from Ajuga pantantha afforded five new neo-clerodane diterpenoids (1–5). The structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. Compounds 2 and 5 were found to have the property of inhibiting NO production (IC50 values < 40 μM). Molecular docking and Western blotting were used to study the mechanism of anti-inflammatory action. Furthermore, compound 5 with the highest activity was tested for its in vivo anti-inflammatory effects using a zebrafish model.

Original languageEnglish
Article number103966
JournalBioorganic Chemistry
Publication statusPublished - 2020 Aug


  • Ajuga pantantha
  • Diterpenoids
  • Inflammation
  • Molecular docking
  • Nitric oxide inhibitory effects
  • Zebrafish model

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry


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