Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha

Wenpei Liu, Ziteng Song, Huimei Wang, Xueyuan Yang, Elizabeth Joubert, Jie Zhang, Shen Li, Muhetaer Tuerhong, Munira Abudukeremu, Jin Jin, Jing Xu, Dongho Lee, Yuanqiang Guo

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    A phytochemical survey to obtain bioactive natural products from Ajuga pantantha afforded five new neo-clerodane diterpenoids (1–5). The structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. Compounds 2 and 5 were found to have the property of inhibiting NO production (IC50 values < 40 μM). Molecular docking and Western blotting were used to study the mechanism of anti-inflammatory action. Furthermore, compound 5 with the highest activity was tested for its in vivo anti-inflammatory effects using a zebrafish model.

    Original languageEnglish
    Article number103966
    JournalBioorganic Chemistry
    Volume101
    DOIs
    Publication statusPublished - 2020 Aug

    Bibliographical note

    Publisher Copyright:
    © 2020 Elsevier Inc.

    Keywords

    • Ajuga pantantha
    • Diterpenoids
    • Inflammation
    • Molecular docking
    • Nitric oxide inhibitory effects
    • Zebrafish model

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Drug Discovery
    • Organic Chemistry

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