Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha

Wenpei Liu; Ziteng Song; Huimei Wang; Xueyuan Yang; Elizabeth Joubert; Jie Zhang; Shen Li; Muhetaer Tuerhong; Munira Abudukeremu; Jin Jin; Jing Xu; Dongho Lee; Yuanqiang Guo

doi:10.1016/j.bioorg.2020.103966

Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha

Wenpei Liu
, Ziteng Song
, Huimei Wang
, Xueyuan Yang
, Elizabeth Joubert
, Jie Zhang
, Shen Li
, Muhetaer Tuerhong
, Munira Abudukeremu
, Jin Jin
, Jing Xu^*
, Dongho Lee
, Yuanqiang Guo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

A phytochemical survey to obtain bioactive natural products from Ajuga pantantha afforded five new neo-clerodane diterpenoids (1–5). The structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. Compounds 2 and 5 were found to have the property of inhibiting NO production (IC₅₀ values < 40 μM). Molecular docking and Western blotting were used to study the mechanism of anti-inflammatory action. Furthermore, compound 5 with the highest activity was tested for its in vivo anti-inflammatory effects using a zebrafish model.

Original language	English
Article number	103966
Journal	Bioorganic Chemistry
Volume	101
DOIs	https://doi.org/10.1016/j.bioorg.2020.103966
Publication status	Published - 2020 Aug

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

Ajuga pantantha
Diterpenoids
Inflammation
Molecular docking
Nitric oxide inhibitory effects
Zebrafish model

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

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10.1016/j.bioorg.2020.103966

Cite this

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title = "Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha",

abstract = "A phytochemical survey to obtain bioactive natural products from Ajuga pantantha afforded five new neo-clerodane diterpenoids (1–5). The structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. Compounds 2 and 5 were found to have the property of inhibiting NO production (IC50 values < 40 μM). Molecular docking and Western blotting were used to study the mechanism of anti-inflammatory action. Furthermore, compound 5 with the highest activity was tested for its in vivo anti-inflammatory effects using a zebrafish model.",

keywords = "Ajuga pantantha, Diterpenoids, Inflammation, Molecular docking, Nitric oxide inhibitory effects, Zebrafish model",

author = "Wenpei Liu and Ziteng Song and Huimei Wang and Xueyuan Yang and Elizabeth Joubert and Jie Zhang and Shen Li and Muhetaer Tuerhong and Munira Abudukeremu and Jin Jin and Jing Xu and Dongho Lee and Yuanqiang Guo",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = aug,

doi = "10.1016/j.bioorg.2020.103966",

language = "English",

volume = "101",

journal = "Bioorganic Chemistry",

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T1 - Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha

AU - Liu, Wenpei

AU - Song, Ziteng

AU - Wang, Huimei

AU - Yang, Xueyuan

AU - Joubert, Elizabeth

AU - Zhang, Jie

AU - Li, Shen

AU - Tuerhong, Muhetaer

AU - Abudukeremu, Munira

AU - Jin, Jin

AU - Xu, Jing

AU - Lee, Dongho

AU - Guo, Yuanqiang

PY - 2020/8

Y1 - 2020/8

N2 - A phytochemical survey to obtain bioactive natural products from Ajuga pantantha afforded five new neo-clerodane diterpenoids (1–5). The structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. Compounds 2 and 5 were found to have the property of inhibiting NO production (IC50 values < 40 μM). Molecular docking and Western blotting were used to study the mechanism of anti-inflammatory action. Furthermore, compound 5 with the highest activity was tested for its in vivo anti-inflammatory effects using a zebrafish model.

AB - A phytochemical survey to obtain bioactive natural products from Ajuga pantantha afforded five new neo-clerodane diterpenoids (1–5). The structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. Compounds 2 and 5 were found to have the property of inhibiting NO production (IC50 values < 40 μM). Molecular docking and Western blotting were used to study the mechanism of anti-inflammatory action. Furthermore, compound 5 with the highest activity was tested for its in vivo anti-inflammatory effects using a zebrafish model.

KW - Ajuga pantantha

KW - Diterpenoids

KW - Inflammation

KW - Molecular docking

KW - Nitric oxide inhibitory effects

KW - Zebrafish model

UR - https://www.scopus.com/pages/publications/85086653127

U2 - 10.1016/j.bioorg.2020.103966

DO - 10.1016/j.bioorg.2020.103966

M3 - Article

C2 - 32506016

AN - SCOPUS:85086653127

SN - 0045-2068

VL - 101

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

M1 - 103966

ER -

Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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