Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects

Jing Xu; Shen Li; Xiaocong Sun; Jun Ma; Feng Liu; Ling Tong; Dongho Lee; Yasushi Ohizumi; Muhetaer Tuerhong; Yuanqiang Guo

doi:10.1016/j.fitote.2016.07.012

Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects

Jing Xu
, Shen Li
, Xiaocong Sun
, Jun Ma
, Feng Liu
, Ling Tong
, Dongho Lee
, Yasushi Ohizumi
, Muhetaer Tuerhong^*
, Yuanqiang Guo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

A phytochemical investigation of the leaves of Callicarpa kwangtungensis led to the isolation of three new diterpenoids (1–3), callipenes A–C, and eleven known analogues (4–14). Their structures were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compounds 1 and 2 are rare abietane diterpenoids possessing a peroxide bridge. All of the isolates were found to inhibit LPS-induced NO production in BV-2 cells.

Original language	English
Pages (from-to)	151-157
Number of pages	7
Journal	Fitoterapia
Volume	113
DOIs	https://doi.org/10.1016/j.fitote.2016.07.012
Publication status	Published - 2016 Sept 1

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China (Nos. 21372125 and 81102331 ), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700 ), and the State Key Laboratory of Medicinal Chemical Biology (No. 201602007 ).

Publisher Copyright:
© 2016

Keywords

Abietane diterpenoids
Callicarpa kwangtungensis
Diterpenoids
NO inhibitory effects
TDDFT ECD calculations

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/j.fitote.2016.07.012

Cite this

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abstract = "A phytochemical investigation of the leaves of Callicarpa kwangtungensis led to the isolation of three new diterpenoids (1–3), callipenes A–C, and eleven known analogues (4–14). Their structures were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compounds 1 and 2 are rare abietane diterpenoids possessing a peroxide bridge. All of the isolates were found to inhibit LPS-induced NO production in BV-2 cells.",

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AU - Xu, Jing

AU - Li, Shen

AU - Sun, Xiaocong

AU - Ma, Jun

AU - Liu, Feng

AU - Tong, Ling

AU - Lee, Dongho

AU - Ohizumi, Yasushi

AU - Tuerhong, Muhetaer

AU - Guo, Yuanqiang

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N2 - A phytochemical investigation of the leaves of Callicarpa kwangtungensis led to the isolation of three new diterpenoids (1–3), callipenes A–C, and eleven known analogues (4–14). Their structures were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compounds 1 and 2 are rare abietane diterpenoids possessing a peroxide bridge. All of the isolates were found to inhibit LPS-induced NO production in BV-2 cells.

AB - A phytochemical investigation of the leaves of Callicarpa kwangtungensis led to the isolation of three new diterpenoids (1–3), callipenes A–C, and eleven known analogues (4–14). Their structures were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compounds 1 and 2 are rare abietane diterpenoids possessing a peroxide bridge. All of the isolates were found to inhibit LPS-induced NO production in BV-2 cells.

KW - Abietane diterpenoids

KW - Callicarpa kwangtungensis

KW - Diterpenoids

KW - NO inhibitory effects

KW - TDDFT ECD calculations

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ER -

Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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