Divalent metal ion-mediated assembly of spherical nucleic acids: the case study of Cu2+

Jang Ho Joo, Jae Seung Lee

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5 Citations (Scopus)


Despite the critical functions of divalent metal ions (M2+s) in association with duplex DNA, fundamental and general interactions of M2+s with spherical nucleic acids (SNAs) composed of single-stranded DNA have rarely been investigated. We have explored that the coordinative nature of the M2+-SNA binding mediates the temperature- and base composition-dependent reversible assemblies of SNAs even without the need of complementary counterparts for duplex-interconnection, additional monovalent metal ions for charge screening, or pre-designed sequences for any non-Watson-Crick base-pairing, all of which are essential for the conventional assembly of SNAs. Cu2+ has been identified to maximize the reversible assembly properties in relation to this M2+-mediated DNA bond, and has been further qualitatively and quantitatively investigated in detail as a model system.

Original languageEnglish
Pages (from-to)30292-30299
Number of pages8
JournalPhysical Chemistry Chemical Physics
Issue number45
Publication statusPublished - 2015 Oct 19

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ASJC Scopus subject areas

  • General Physics and Astronomy
  • Physical and Theoretical Chemistry


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