Divalent metal ion-mediated assembly of spherical nucleic acids: the case study of Cu2+

Jang Ho Joo; Jae Seung Lee

doi:10.1039/c5cp05202e

Divalent metal ion-mediated assembly of spherical nucleic acids: the case study of Cu²⁺

Jang Ho Joo, Jae Seung Lee

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Despite the critical functions of divalent metal ions (M²⁺s) in association with duplex DNA, fundamental and general interactions of M²⁺s with spherical nucleic acids (SNAs) composed of single-stranded DNA have rarely been investigated. We have explored that the coordinative nature of the M²⁺-SNA binding mediates the temperature- and base composition-dependent reversible assemblies of SNAs even without the need of complementary counterparts for duplex-interconnection, additional monovalent metal ions for charge screening, or pre-designed sequences for any non-Watson-Crick base-pairing, all of which are essential for the conventional assembly of SNAs. Cu²⁺ has been identified to maximize the reversible assembly properties in relation to this M²⁺-mediated DNA bond, and has been further qualitatively and quantitatively investigated in detail as a model system.

Original language	English
Pages (from-to)	30292-30299
Number of pages	8
Journal	Physical Chemistry Chemical Physics
Volume	17
Issue number	45
DOIs	https://doi.org/10.1039/c5cp05202e
Publication status	Published - 2015 Oct 19

Bibliographical note

Publisher Copyright:
© the Owner Societies.

ASJC Scopus subject areas

Physics and Astronomy(all)
Physical and Theoretical Chemistry

Access to Document

10.1039/c5cp05202e

Cite this

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abstract = "Despite the critical functions of divalent metal ions (M2+s) in association with duplex DNA, fundamental and general interactions of M2+s with spherical nucleic acids (SNAs) composed of single-stranded DNA have rarely been investigated. We have explored that the coordinative nature of the M2+-SNA binding mediates the temperature- and base composition-dependent reversible assemblies of SNAs even without the need of complementary counterparts for duplex-interconnection, additional monovalent metal ions for charge screening, or pre-designed sequences for any non-Watson-Crick base-pairing, all of which are essential for the conventional assembly of SNAs. Cu2+ has been identified to maximize the reversible assembly properties in relation to this M2+-mediated DNA bond, and has been further qualitatively and quantitatively investigated in detail as a model system.",

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