Divergent lineage of a novel hantavirus in the banana pipistrelle (Neoromicia nanus) in Côte d'Ivoire

Laarni Sumibcay; Blaise Kadjo; Se Hun Gu; Hae Ji Kang; Burton K. Lim; Joseph A. Cook; Jin Won Song; Richard Yanagihara

doi:10.1186/1743-422X-9-34

Divergent lineage of a novel hantavirus in the banana pipistrelle (Neoromicia nanus) in Côte d'Ivoire

Laarni Sumibcay
, Blaise Kadjo
, Se Hun Gu
, Hae Ji Kang
, Burton K. Lim
, Joseph A. Cook
, Jin Won Song
, Richard Yanagihara^*

^*Corresponding author for this work

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

Abstract

Recently identified hantaviruses harbored by shrews and moles (order Soricomorpha) suggest that other mammals having shared ancestry may serve as reservoirs. To investigate this possibility, archival tissues from 213 insectivorous bats (order Chiroptera) were analyzed for hantavirus RNA by RT-PCR. Following numerous failed attempts, hantavirus RNA was detected in ethanol-fixed liver tissue from two banana pipistrelles (Neoromicia nanus), captured near Mouyassué village in Côte d'Ivoire, West Africa, in June 2011. Phylogenetic analysis of partial L-segment sequences using maximum-likelihood and Bayesian methods revealed that the newfound hantavirus, designated Mouyassué virus (MOUV), was highly divergent and basal to all other rodent- and soricomorph-borne hantaviruses, except for Nova virus in the European common mole (Talpa europaea). Full genome sequencing of MOUV and further surveys of other bat species for hantaviruses, now underway, will provide critical insights into the evolution and diversification of hantaviruses.

Original language	English
Article number	34
Journal	Virology Journal
Volume	9
DOIs	https://doi.org/10.1186/1743-422X-9-34
Publication status	Published - 2012

Bibliographical note

Funding Information:
We thank Melissa S. Nagata, Nelson I.B. Lazaga, Moti L. Chapagain and Pakieli H. Kaufusi for technical assistance. We also thank Shaobin Hou and the staff of the Advanced Studies in Genomics, Proteomics and Bioinformatics for DNA sequencing. This work was supported in part by grants R01AI075057 from the National Institute of Allergy and Infectious Diseases and P20GM103516 from the National Institute of General Medical Sciences, National Institutes of Health.

Keywords

Africa
Bat
Côte d'Ivoire
Hantavirus
Phylogeny

ASJC Scopus subject areas

Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1743-422X-9-34

Cite this

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title = "Divergent lineage of a novel hantavirus in the banana pipistrelle (Neoromicia nanus) in C{\^o}te d'Ivoire",

abstract = "Recently identified hantaviruses harbored by shrews and moles (order Soricomorpha) suggest that other mammals having shared ancestry may serve as reservoirs. To investigate this possibility, archival tissues from 213 insectivorous bats (order Chiroptera) were analyzed for hantavirus RNA by RT-PCR. Following numerous failed attempts, hantavirus RNA was detected in ethanol-fixed liver tissue from two banana pipistrelles (Neoromicia nanus), captured near Mouyassu{\'e} village in C{\^o}te d'Ivoire, West Africa, in June 2011. Phylogenetic analysis of partial L-segment sequences using maximum-likelihood and Bayesian methods revealed that the newfound hantavirus, designated Mouyassu{\'e} virus (MOUV), was highly divergent and basal to all other rodent- and soricomorph-borne hantaviruses, except for Nova virus in the European common mole (Talpa europaea). Full genome sequencing of MOUV and further surveys of other bat species for hantaviruses, now underway, will provide critical insights into the evolution and diversification of hantaviruses.",

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author = "Laarni Sumibcay and Blaise Kadjo and Gu, \{Se Hun\} and Kang, \{Hae Ji\} and Lim, \{Burton K.\} and Cook, \{Joseph A.\} and Song, \{Jin Won\} and Richard Yanagihara",

note = "Funding Information: We thank Melissa S. Nagata, Nelson I.B. Lazaga, Moti L. Chapagain and Pakieli H. Kaufusi for technical assistance. We also thank Shaobin Hou and the staff of the Advanced Studies in Genomics, Proteomics and Bioinformatics for DNA sequencing. This work was supported in part by grants R01AI075057 from the National Institute of Allergy and Infectious Diseases and P20GM103516 from the National Institute of General Medical Sciences, National Institutes of Health.",

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doi = "10.1186/1743-422X-9-34",

language = "English",

volume = "9",

journal = "Virology Journal",

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AU - Kadjo, Blaise

AU - Gu, Se Hun

AU - Kang, Hae Ji

AU - Lim, Burton K.

AU - Cook, Joseph A.

AU - Song, Jin Won

AU - Yanagihara, Richard

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PY - 2012

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N2 - Recently identified hantaviruses harbored by shrews and moles (order Soricomorpha) suggest that other mammals having shared ancestry may serve as reservoirs. To investigate this possibility, archival tissues from 213 insectivorous bats (order Chiroptera) were analyzed for hantavirus RNA by RT-PCR. Following numerous failed attempts, hantavirus RNA was detected in ethanol-fixed liver tissue from two banana pipistrelles (Neoromicia nanus), captured near Mouyassué village in Côte d'Ivoire, West Africa, in June 2011. Phylogenetic analysis of partial L-segment sequences using maximum-likelihood and Bayesian methods revealed that the newfound hantavirus, designated Mouyassué virus (MOUV), was highly divergent and basal to all other rodent- and soricomorph-borne hantaviruses, except for Nova virus in the European common mole (Talpa europaea). Full genome sequencing of MOUV and further surveys of other bat species for hantaviruses, now underway, will provide critical insights into the evolution and diversification of hantaviruses.

AB - Recently identified hantaviruses harbored by shrews and moles (order Soricomorpha) suggest that other mammals having shared ancestry may serve as reservoirs. To investigate this possibility, archival tissues from 213 insectivorous bats (order Chiroptera) were analyzed for hantavirus RNA by RT-PCR. Following numerous failed attempts, hantavirus RNA was detected in ethanol-fixed liver tissue from two banana pipistrelles (Neoromicia nanus), captured near Mouyassué village in Côte d'Ivoire, West Africa, in June 2011. Phylogenetic analysis of partial L-segment sequences using maximum-likelihood and Bayesian methods revealed that the newfound hantavirus, designated Mouyassué virus (MOUV), was highly divergent and basal to all other rodent- and soricomorph-borne hantaviruses, except for Nova virus in the European common mole (Talpa europaea). Full genome sequencing of MOUV and further surveys of other bat species for hantaviruses, now underway, will provide critical insights into the evolution and diversification of hantaviruses.

KW - Africa

KW - Bat

KW - Côte d'Ivoire

KW - Hantavirus

KW - Phylogeny

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Divergent lineage of a novel hantavirus in the banana pipistrelle (Neoromicia nanus) in Côte d'Ivoire

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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