Abstract
Synthetic molecules that modulate and probe biological events are critical tools in chemical biology. Utilizing combinatorial and diversity-oriented synthetic strategies, access to large numbers of small molecules is becoming more and more feasible, and research groups in this field can take advantage of the power of chemical diversity. Since the majority of early studies were focused on the discovery of compounds that perturb protein functions, diversity-based approaches are often considered as therapeutic lead discovery tactics. However, the diversity-oriented approach can also be applied to advance distinct aims, such as target protein identification, or the development of imaging probes and sensors. This review provides a personal perspective of the chemical-diversity-based approach and how this principle can be adapted to various chemical biology studies. The diversity-driven approach to chemical biology is reviewed from a personal perspective, including a discussion of how this principle can be adapted to advance various chemical biology studies, such as target protein identification, the development of imaging probes and sensors, and differential sensing.
Original language | English |
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Pages (from-to) | 495-510 |
Number of pages | 16 |
Journal | Chemical Record |
Volume | 15 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2015 Apr 1 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2015 The Chemical Society of Japan and Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keywords
- fluorescent probes
- high-throughput screening
- molecular diversity
- sensors
- target identification
ASJC Scopus subject areas
- General Chemistry
- Biochemistry
- General Chemical Engineering
- Materials Chemistry