Diversity-oriented optical imaging probe development

Jun Seok Lee; Marc Vendrell; Young Tae Chang

doi:10.1016/j.cbpa.2011.10.007

Diversity-oriented optical imaging probe development

Jun Seok Lee, Marc Vendrell, Young Tae Chang

Research output: Contribution to journal › Review article › peer-review

36 Citations (Scopus)

Abstract

The development of optical probes is receiving considerable attention due to their rising adaptation in diagnostics and medical imaging. Diversity-oriented approaches make use of combinatorial chemistry and high-throughput screenings to enrich the spectral and structural variety of these probes and effectively identify those with specific properties (e.g. molecular affinity, cellular selectivity, high photostability, and sensitivity). Herein we review recent examples in which diversity-driven strategies have assisted the discovery of new molecular imaging probes.

Original language	English
Pages (from-to)	760-767
Number of pages	8
Journal	Current Opinion in Chemical Biology
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.cbpa.2011.10.007
Publication status	Published - 2011 Dec
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by an intramural funding from A*STAR (Agency for Science, Technology and Research Singapore) Biomedical Research Council , A*STAR SSCC Grant ( SSCC10/024 ), and Converging Research Center Program through the Ministry of Education, Science and Technology, Korea ( 2010K001410 ). J.-S. Lee is a recipient of TJ Park Science Fellowship.

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

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10.1016/j.cbpa.2011.10.007

Cite this

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title = "Diversity-oriented optical imaging probe development",

abstract = "The development of optical probes is receiving considerable attention due to their rising adaptation in diagnostics and medical imaging. Diversity-oriented approaches make use of combinatorial chemistry and high-throughput screenings to enrich the spectral and structural variety of these probes and effectively identify those with specific properties (e.g. molecular affinity, cellular selectivity, high photostability, and sensitivity). Herein we review recent examples in which diversity-driven strategies have assisted the discovery of new molecular imaging probes.",

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doi = "10.1016/j.cbpa.2011.10.007",

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AU - Chang, Young Tae

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N2 - The development of optical probes is receiving considerable attention due to their rising adaptation in diagnostics and medical imaging. Diversity-oriented approaches make use of combinatorial chemistry and high-throughput screenings to enrich the spectral and structural variety of these probes and effectively identify those with specific properties (e.g. molecular affinity, cellular selectivity, high photostability, and sensitivity). Herein we review recent examples in which diversity-driven strategies have assisted the discovery of new molecular imaging probes.

AB - The development of optical probes is receiving considerable attention due to their rising adaptation in diagnostics and medical imaging. Diversity-oriented approaches make use of combinatorial chemistry and high-throughput screenings to enrich the spectral and structural variety of these probes and effectively identify those with specific properties (e.g. molecular affinity, cellular selectivity, high photostability, and sensitivity). Herein we review recent examples in which diversity-driven strategies have assisted the discovery of new molecular imaging probes.

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Diversity-oriented optical imaging probe development

Abstract

Bibliographical note

ASJC Scopus subject areas

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