The development of optical probes is receiving considerable attention due to their rising adaptation in diagnostics and medical imaging. Diversity-oriented approaches make use of combinatorial chemistry and high-throughput screenings to enrich the spectral and structural variety of these probes and effectively identify those with specific properties (e.g. molecular affinity, cellular selectivity, high photostability, and sensitivity). Herein we review recent examples in which diversity-driven strategies have assisted the discovery of new molecular imaging probes.
Bibliographical noteFunding Information:
This work was supported by an intramural funding from A*STAR (Agency for Science, Technology and Research Singapore) Biomedical Research Council , A*STAR SSCC Grant ( SSCC10/024 ), and Converging Research Center Program through the Ministry of Education, Science and Technology, Korea ( 2010K001410 ). J.-S. Lee is a recipient of TJ Park Science Fellowship.
ASJC Scopus subject areas
- Analytical Chemistry