DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication

Kevin S. Paulsen, Yanxiang Deng, Aram J. Chung

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Complex-shaped microparticles can enhance applications in drug delivery, tissue engineering, and structural materials, although techniques to fabricate these particles remain limited. A microfluidics-based process called optofluidic fabrication that utilizes inertial flows and ultraviolet polymerization has shown great potential for creating highly 3D-shaped particles in a high-throughput manner, but the particle dimensions are mainly at the millimeter scale. Here, a next generation optofluidic fabrication process is presented that utilizes on-the-fly fabricated multiscale fluidic channels producing customized sub-100 µm 3D-shaped microparticles. This flexible design scheme offers a user-friendly platform for rapid prototyping of new 3D particle shapes, providing greater potential for creating impactful engineered microparticles.

Original languageEnglish
Article number1800252
JournalAdvanced Science
Issue number7
Publication statusPublished - 2018 Jul

Bibliographical note

Publisher Copyright:
© 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim


  • 3D microparticles
  • inertial microfluidics
  • optofluidic fabrication
  • optofluidics

ASJC Scopus subject areas

  • General Engineering
  • General Chemical Engineering
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • General Materials Science
  • General Physics and Astronomy
  • Medicine (miscellaneous)


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