DNA-embedding Schiff base molecule assemblies: an efficient biological detection approach based on clustering-triggered emission

Danning Lv, Jingyuan Huang, Xianyang Li, Chunzhi Cui, Dong June Ahn

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, we prepared novel hybrid assemblies composed of a small Schiff base molecule, (E)-1-(4-(dimethylamino)-phenyl)iminomethyl-2-hydroxyl-naphthalene (DPIN), and single strand DNAs (ssDNAs). Owing to clustering-triggered emission (CTE), aggregated hybrid assemblies emit a strong fluorescence signal. However, after incubation with specific target DNA (tDNA) sequences, the formed double helical DNAs dispersed the hybrid assemblies and contributed to the decrease in the fluorescence signal. By contrast, the cases of 1-mer and random mismatched tDNA sequences did not show any such diminished fluorescence signal.

Original languageEnglish
Pages (from-to)9040-9044
Number of pages5
JournalNew Journal of Chemistry
Volume47
Issue number19
DOIs
Publication statusPublished - 2023 Apr 18

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China (52011540402 and 21865037), the National Research Foundation of Korea (2021R1A2C3009955 and 2017M3D1A1039421), 111 Project (D18012), and Korea University Grant.

Publisher Copyright:
© 2023 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Materials Chemistry

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