DNA-embedding Schiff base molecule assemblies: an efficient biological detection approach based on clustering-triggered emission

Danning Lv; Jingyuan Huang; Xianyang Li; Chunzhi Cui; Dong June Ahn

doi:10.1039/d3nj01240a

DNA-embedding Schiff base molecule assemblies: an efficient biological detection approach based on clustering-triggered emission

Danning Lv
, Jingyuan Huang
, Xianyang Li
, Chunzhi Cui^*
, Dong June Ahn^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

In this study, we prepared novel hybrid assemblies composed of a small Schiff base molecule, (E)-1-(4-(dimethylamino)-phenyl)iminomethyl-2-hydroxyl-naphthalene (DPIN), and single strand DNAs (ssDNAs). Owing to clustering-triggered emission (CTE), aggregated hybrid assemblies emit a strong fluorescence signal. However, after incubation with specific target DNA (tDNA) sequences, the formed double helical DNAs dispersed the hybrid assemblies and contributed to the decrease in the fluorescence signal. By contrast, the cases of 1-mer and random mismatched tDNA sequences did not show any such diminished fluorescence signal.

Original language	English
Pages (from-to)	9040-9044
Number of pages	5
Journal	New Journal of Chemistry
Volume	47
Issue number	19
DOIs	https://doi.org/10.1039/d3nj01240a
Publication status	Published - 2023 Apr 18

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China (52011540402 and 21865037), the National Research Foundation of Korea (2021R1A2C3009955 and 2017M3D1A1039421), 111 Project (D18012), and Korea University Grant.

Publisher Copyright:
© 2023 The Royal Society of Chemistry.

ASJC Scopus subject areas

Catalysis
General Chemistry
Materials Chemistry

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10.1039/d3nj01240a

Cite this

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title = "DNA-embedding Schiff base molecule assemblies: an efficient biological detection approach based on clustering-triggered emission",

abstract = "In this study, we prepared novel hybrid assemblies composed of a small Schiff base molecule, (E)-1-(4-(dimethylamino)-phenyl)iminomethyl-2-hydroxyl-naphthalene (DPIN), and single strand DNAs (ssDNAs). Owing to clustering-triggered emission (CTE), aggregated hybrid assemblies emit a strong fluorescence signal. However, after incubation with specific target DNA (tDNA) sequences, the formed double helical DNAs dispersed the hybrid assemblies and contributed to the decrease in the fluorescence signal. By contrast, the cases of 1-mer and random mismatched tDNA sequences did not show any such diminished fluorescence signal.",

author = "Danning Lv and Jingyuan Huang and Xianyang Li and Chunzhi Cui and Ahn, \{Dong June\}",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (52011540402 and 21865037), the National Research Foundation of Korea (2021R1A2C3009955 and 2017M3D1A1039421), 111 Project (D18012), and Korea University Grant. Publisher Copyright: {\textcopyright} 2023 The Royal Society of Chemistry.",

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doi = "10.1039/d3nj01240a",

language = "English",

volume = "47",

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TY - JOUR

T1 - DNA-embedding Schiff base molecule assemblies

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AU - Lv, Danning

AU - Huang, Jingyuan

AU - Li, Xianyang

AU - Cui, Chunzhi

AU - Ahn, Dong June

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (52011540402 and 21865037), the National Research Foundation of Korea (2021R1A2C3009955 and 2017M3D1A1039421), 111 Project (D18012), and Korea University Grant. Publisher Copyright: © 2023 The Royal Society of Chemistry.

PY - 2023/4/18

Y1 - 2023/4/18

N2 - In this study, we prepared novel hybrid assemblies composed of a small Schiff base molecule, (E)-1-(4-(dimethylamino)-phenyl)iminomethyl-2-hydroxyl-naphthalene (DPIN), and single strand DNAs (ssDNAs). Owing to clustering-triggered emission (CTE), aggregated hybrid assemblies emit a strong fluorescence signal. However, after incubation with specific target DNA (tDNA) sequences, the formed double helical DNAs dispersed the hybrid assemblies and contributed to the decrease in the fluorescence signal. By contrast, the cases of 1-mer and random mismatched tDNA sequences did not show any such diminished fluorescence signal.

AB - In this study, we prepared novel hybrid assemblies composed of a small Schiff base molecule, (E)-1-(4-(dimethylamino)-phenyl)iminomethyl-2-hydroxyl-naphthalene (DPIN), and single strand DNAs (ssDNAs). Owing to clustering-triggered emission (CTE), aggregated hybrid assemblies emit a strong fluorescence signal. However, after incubation with specific target DNA (tDNA) sequences, the formed double helical DNAs dispersed the hybrid assemblies and contributed to the decrease in the fluorescence signal. By contrast, the cases of 1-mer and random mismatched tDNA sequences did not show any such diminished fluorescence signal.

UR - https://www.scopus.com/pages/publications/85159782737

U2 - 10.1039/d3nj01240a

DO - 10.1039/d3nj01240a

M3 - Article

AN - SCOPUS:85159782737

SN - 1144-0546

VL - 47

SP - 9040

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JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 19

ER -

DNA-embedding Schiff base molecule assemblies: an efficient biological detection approach based on clustering-triggered emission

Abstract

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