Does delayed facial involvement implicate a pattern of "descending reversible paralysis" in Fisher syndrome?

Jong Kuk Kim, Byung Jo Kim, Ha Young Shin, Kyong Jin Shin, Tai Seung Nam, Jung Im Seok, Bum Chun Suh, Jeeyoung Oh, Yeo Jung Kim, Jong Seok Bae

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12 Citations (Scopus)


Abstract Objective Delayed facial palsy (DFP) has often been described during the recovery stage of Fisher syndrome (FS), but the implications of DFP in FS pathophysiology have not been reported previously. The aim of this study was to identify the incidence and clinical course of DFP in FS, and to determine its clinical/pathophysiological implications in FS. Methods About 71 FS patients were enrolled from seven university-based hospitals in Korea. DFP was defined with respect to new development of unilateral or bilateral facial palsies with delayed onset after either the nadir or improvement of initial neurological signs of FS. Results Eleven of the 71 patients (16%) satisfied the definition of DFP. No other cranial palsies developed as a delayed pattern. With the exception of two patients with bulbar involvement, DFP developed after a latent period of upper-cranial neuropathies. Comparison of FS patients without and with DFP revealed no significant clinical, serological, or electrophysiological differences. All except one patient with DFP exhibited a good outcome within 1 month of follow-up. Conclusion DFP was identified as a common and specific phenomenon in FS. Nearly all cases of DFP were developed in a descending manner and were associated with a good outcome, while other cranial neuropathies developed or followed as a sequential pattern. These findings suggest the involvement of so-called "descending reversible paralysis" in the pathophysiology of FS.

Original languageEnglish
Article number4058
Pages (from-to)1-5
Number of pages5
JournalClinical Neurology and Neurosurgery
Publication statusPublished - 2015 Aug 1
Externally publishedYes


  • Delayed
  • Facial nerve
  • Fisher syndrome
  • Paralysis
  • Pathophysiology

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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