Does diabetes mellitus influence carpal tunnel syndrome?

Yoo Hwan Kim, Kyung Sook Yang, Hanjun Kim, Hung Youl Seok, Jung Hun Lee, Myeong Hun Son, Byung Jo Kim

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Background and Purpose Diabetes mellitus (DM) has been proposed as a risk factor for carpal tunnel syndrome (CTS), but this remains controversial. We investigated the association between DM and CTS using both ultrasonography (US) and nerve conduction study (NCS) data. Methods We analyzed a prospectively recruited database of neuromuscular US and medical records of subjects who had undergone NCSs and electromyography for symptoms suggestive of CTS. Subjects were assigned to the follow groups: Group I, CTS with DM; Group II, CTS without DM; Group III, no CTS with DM; and Group IV, no CTS without DM. US cross-sectional area (CSA) and NCS measurements at the median nerve (MN) were compared among groups. We used a general linear mixed model to adjust for statistically significant covariates. Results The 230 participants comprised 22, 83, 19, and 106 in Groups I–IV, respectively. In multivariate analyses, the MN action potential amplitude in females was the only variable that was significantly associated with DM (p<0.001). Groups with DM tended to have a longer latency, smaller amplitude, and lower conduction velocity in the NCSs compared to groups without DM. The measured US CSA values did not differ significantly among the groups. Conclusions NCS measurements of the MN tended to differ between DM and non-DM patients regardless of the presence or absence of CTS. However, US did not reveal any statistically significant relationship between CTS and DM.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalJournal of Clinical Neurology (Korea)
Issue number3
Publication statusPublished - 2017
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP; no. NRF-2015 R1A5A70 37674).

Publisher Copyright:
© 2017 Korean Neurological Association.


  • Carpal tunnel syndrome
  • Diabetes mellitus
  • Ultrasonography

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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