Dopamine D2 receptor-mediated epidermal growth factor receptor transactivation through a disintegrin and metalloprotease regulates dopaminergic neuron development via extracellular signal-related kinase activation

Sehyoun Yoon; Ja Hyun Baik

doi:10.1074/jbc.M113.461202

Dopamine D2 receptor-mediated epidermal growth factor receptor transactivation through a disintegrin and metalloprotease regulates dopaminergic neuron development via extracellular signal-related kinase activation

Sehyoun Yoon, Ja Hyun Baik

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Background:Dopamine D2R-mediated ERK activation regulates dopaminergic neuronal development. Results:D2R activation induces shedding of heparin-binding EGF by activating a disintegrin and metalloproteinase (ADAM) 10 or 17, causing EGFR transactivation in mesencephalic neurons. Conclusion:D2R-mediated ERK activation regulates mesencephalic dopaminergic neuron development via EGFR transactivation through ADAM10/17. Significance:Dopaminergic system alteration through D2R-ADAM-EGFR signaling maybe associated with dopamine-related neurological/psychiatric disorders.

Original language	English
Pages (from-to)	28435-28446
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	40
DOIs	https://doi.org/10.1074/jbc.M113.461202
Publication status	Published - 2013 Oct 4

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Dopamine D2 receptor-mediated epidermal growth factor receptor transactivation through a disintegrin and metalloprotease regulates dopaminergic neuron development via extracellular signal-related kinase activation. / Yoon, Sehyoun; Baik, Ja Hyun.
In: Journal of Biological Chemistry, Vol. 288, No. 40, 04.10.2013, p. 28435-28446.

Research output: Contribution to journal › Article › peer-review

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AB - Background:Dopamine D2R-mediated ERK activation regulates dopaminergic neuronal development. Results:D2R activation induces shedding of heparin-binding EGF by activating a disintegrin and metalloproteinase (ADAM) 10 or 17, causing EGFR transactivation in mesencephalic neurons. Conclusion:D2R-mediated ERK activation regulates mesencephalic dopaminergic neuron development via EGFR transactivation through ADAM10/17. Significance:Dopaminergic system alteration through D2R-ADAM-EGFR signaling maybe associated with dopamine-related neurological/psychiatric disorders.

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Dopamine D2 receptor-mediated epidermal growth factor receptor transactivation through a disintegrin and metalloprotease regulates dopaminergic neuron development via extracellular signal-related kinase activation

Abstract

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