Dopaminergic control of the feeding circuit

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)


There is increasing evidence demonstrating that reward-related motivational food intake is closely connected with the brain’s homeostatic system of energy balance and that this interaction might be important in the integrative control of feeding behavior. Dopamine regulates motivational behavior, including feeding behaviors, and the dopamine reward system is recognized as the most prominent system that controls appetite and motivational and emotional drives for food. It appears that the dopamine system exerts a critical role in the control of feeding behavior not only by the reward-related circuit, but also by contributing to the homeostatic circuit of food intake, suggesting that dopamine plays an integrative role across the converging circuitry of control of food intake by linking energy state-associated signals to reward-related behaviors. This review will cover and discuss up-to-date findings on the dopaminergic control of food intake by both the reward-related circuit and the homeostatic hypothalamic system.

Original languageEnglish
Pages (from-to)229-239
Number of pages11
JournalEndocrinology and Metabolism
Issue number2
Publication statusPublished - 2021 Apr

Bibliographical note

Funding Information:
This work was supported by the Bio & Medical Technology

Funding Information:
Development Program (grant nos. 2013M3A9D5072550 and 2016M3A9D5A01952412), the Mid-Career Researcher Program (grant no. NRF-2020R1A2C2101010) from the National Research Foundation of Korea (NRF) by the Ministry of Science, ICT & Future Planning, and a Korea University grant.

Publisher Copyright:
Copyright © 2021 Korean Endocrine Society.


  • Dopamine
  • Feeding behavior
  • Homeostasis
  • Hypothalamus
  • Reward

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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