Dorsal column lesion reduces mechanical allodynia in the induction, but not the maintenance, phase in spinal hemisected rats

Junesun Kim; Seung Keun Back; Young Wook Yoon; Seung Kil Hong; Heung Sik Na

doi:10.1016/j.neulet.2004.12.074

Dorsal column lesion reduces mechanical allodynia in the induction, but not the maintenance, phase in spinal hemisected rats

Junesun Kim, Seung Keun Back, Young Wook Yoon, Seung Kil Hong, Heung Sik Na

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The dorsal column-medial lemniscal (DC-ML) system is known to be a route of ascending input signals for mechanical allodynia following peripheral nerve injury. We examined whether the pain signals after spinal hemisection were transmitted via the DC-ML system in the induction and maintenance phases of the neuropathic pain. Under enflurane anesthesia, rats were subjected to spinal hemisection at T13 level and bilateral DC lesion was made at T8 level 1 day or 3 weeks after the hemisection. The DC lesion 1 day after the hemisection significantly reduced the mechanical, but not cold, allodynia, whereas the DC lesion 3 weeks after the hemisection did not change both mechanical and cold allodynia. These results suggest that the signals for mechanical allodynia following spinal hemisection should be transmitted via the DC-ML system in the induction, but not maintenance, phase.

Original language	English
Pages (from-to)	218-222
Number of pages	5
Journal	Neuroscience Letters
Volume	379
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2004.12.074
Publication status	Published - 2005 May 13

Bibliographical note

Funding Information:
This research was supported by a grant (M103KV01000903K220100910) from Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology of Republic of Korea.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

Central neuropathic pain
Cold allodynia
Dorsal column-medial lemniscal system
Mechanical allodynia
Spinal cord injury
Spinal hemisection

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2004.12.074

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title = "Dorsal column lesion reduces mechanical allodynia in the induction, but not the maintenance, phase in spinal hemisected rats",

abstract = "The dorsal column-medial lemniscal (DC-ML) system is known to be a route of ascending input signals for mechanical allodynia following peripheral nerve injury. We examined whether the pain signals after spinal hemisection were transmitted via the DC-ML system in the induction and maintenance phases of the neuropathic pain. Under enflurane anesthesia, rats were subjected to spinal hemisection at T13 level and bilateral DC lesion was made at T8 level 1 day or 3 weeks after the hemisection. The DC lesion 1 day after the hemisection significantly reduced the mechanical, but not cold, allodynia, whereas the DC lesion 3 weeks after the hemisection did not change both mechanical and cold allodynia. These results suggest that the signals for mechanical allodynia following spinal hemisection should be transmitted via the DC-ML system in the induction, but not maintenance, phase.",

keywords = "Central neuropathic pain, Cold allodynia, Dorsal column-medial lemniscal system, Mechanical allodynia, Spinal cord injury, Spinal hemisection",

author = "Junesun Kim and Back, {Seung Keun} and Yoon, {Young Wook} and Hong, {Seung Kil} and Na, {Heung Sik}",

note = "Funding Information: This research was supported by a grant (M103KV01000903K220100910) from Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology of Republic of Korea. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.neulet.2004.12.074",

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AU - Kim, Junesun

AU - Back, Seung Keun

AU - Yoon, Young Wook

AU - Hong, Seung Kil

AU - Na, Heung Sik

N1 - Funding Information: This research was supported by a grant (M103KV01000903K220100910) from Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology of Republic of Korea. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2005/5/13

Y1 - 2005/5/13

N2 - The dorsal column-medial lemniscal (DC-ML) system is known to be a route of ascending input signals for mechanical allodynia following peripheral nerve injury. We examined whether the pain signals after spinal hemisection were transmitted via the DC-ML system in the induction and maintenance phases of the neuropathic pain. Under enflurane anesthesia, rats were subjected to spinal hemisection at T13 level and bilateral DC lesion was made at T8 level 1 day or 3 weeks after the hemisection. The DC lesion 1 day after the hemisection significantly reduced the mechanical, but not cold, allodynia, whereas the DC lesion 3 weeks after the hemisection did not change both mechanical and cold allodynia. These results suggest that the signals for mechanical allodynia following spinal hemisection should be transmitted via the DC-ML system in the induction, but not maintenance, phase.

AB - The dorsal column-medial lemniscal (DC-ML) system is known to be a route of ascending input signals for mechanical allodynia following peripheral nerve injury. We examined whether the pain signals after spinal hemisection were transmitted via the DC-ML system in the induction and maintenance phases of the neuropathic pain. Under enflurane anesthesia, rats were subjected to spinal hemisection at T13 level and bilateral DC lesion was made at T8 level 1 day or 3 weeks after the hemisection. The DC lesion 1 day after the hemisection significantly reduced the mechanical, but not cold, allodynia, whereas the DC lesion 3 weeks after the hemisection did not change both mechanical and cold allodynia. These results suggest that the signals for mechanical allodynia following spinal hemisection should be transmitted via the DC-ML system in the induction, but not maintenance, phase.

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KW - Mechanical allodynia

KW - Spinal cord injury

KW - Spinal hemisection

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Dorsal column lesion reduces mechanical allodynia in the induction, but not the maintenance, phase in spinal hemisected rats

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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