The dorsal column-medial lemniscal (DC-ML) system is known to be a route of ascending input signals for mechanical allodynia following peripheral nerve injury. We examined whether the pain signals after spinal hemisection were transmitted via the DC-ML system in the induction and maintenance phases of the neuropathic pain. Under enflurane anesthesia, rats were subjected to spinal hemisection at T13 level and bilateral DC lesion was made at T8 level 1 day or 3 weeks after the hemisection. The DC lesion 1 day after the hemisection significantly reduced the mechanical, but not cold, allodynia, whereas the DC lesion 3 weeks after the hemisection did not change both mechanical and cold allodynia. These results suggest that the signals for mechanical allodynia following spinal hemisection should be transmitted via the DC-ML system in the induction, but not maintenance, phase.
Bibliographical noteFunding Information:
This research was supported by a grant (M103KV01000903K220100910) from Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology of Republic of Korea.
Copyright 2017 Elsevier B.V., All rights reserved.
- Central neuropathic pain
- Cold allodynia
- Dorsal column-medial lemniscal system
- Mechanical allodynia
- Spinal cord injury
- Spinal hemisection
ASJC Scopus subject areas
- General Neuroscience