Double-layer magnetic nanoparticle-embedded silica particles for efficient bio-separation

San Kyeong, Cheolhwan Jeong, Homan Kang, Hong Jun Cho, Sung Jun Park, Jin Kyoung Yang, Sehoon Kim, Hyung Mo Kim, Bong Hyun Jun, Yoon Sik Lee

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Superparamagnetic Fe3O4 nanoparticles (NPs) based nanomaterials have been exploited in various biotechnology fields including biomolecule separation. However, slow accumulation of Fe3O4 NPs by magnets may limit broad applications of Fe3O4 NP-based nanomaterials. In this study, we report fabrication of Fe3O4 NPs double-layered silica nanoparticles (DL MNPs) with a silica core and highly packed Fe3O4 NPs layers. The DL MNPs had a superparamagnetic property and efficient accumulation kinetics under an external magnetic field. Moreover, the magnetic field-exposed DL MNPs show quantitative accumulation, whereas Fe3O4 NPs single-layered silica nanoparticles (SL MNPs) and silica-coated Fe3O4 NPs produced a saturated plateau under full recovery of the NPs. DL MNPs are promising nanomaterials with great potential to separate and analyze biomolecules.

Original languageEnglish
Article numbere0143727
JournalPloS one
Issue number11
Publication statusPublished - 2015 Nov 1

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning( 2014-A002-0065). Consulting service from Microbial Carbohydrate Resource Bank (MCRB) is gratefully acknowledged.

Publisher Copyright:
© 2015 Kyeong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • General


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