Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

Kyoung Ran Kim; Da Rae Kim; Taemin Lee; Ji Young Yhee; Byeong Su Kim; Ick Chan Kwon; Dae Ro Ahn

doi:10.1039/c3cc38693g

Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

Kyoung Ran Kim, Da Rae Kim, Taemin Lee, Ji Young Yhee, Byeong Su Kim, Ick Chan Kwon, Dae Ro Ahn

KU-KIST Graduate School of Converging Science and Technology

Research output: Contribution to journal › Article › peer-review

196 Citations (Scopus)

Abstract

A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.

Original language	English
Pages (from-to)	2010-2012
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	20
DOIs	https://doi.org/10.1039/c3cc38693g
Publication status	Published - 2013 Feb 12

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c3cc38693g

Cite this

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abstract = "A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.",

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AU - Kim, Kyoung Ran

AU - Kim, Da Rae

AU - Lee, Taemin

AU - Yhee, Ji Young

AU - Kim, Byeong Su

AU - Kwon, Ick Chan

AU - Ahn, Dae Ro

PY - 2013/2/12

Y1 - 2013/2/12

N2 - A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.

AB - A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.

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Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

Abstract

ASJC Scopus subject areas

UN SDGs

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