TY - JOUR
T1 - Drug release from electric current sensitive polymers
AU - Kwon, Ick Chan
AU - Bae, You Han
AU - Okano, Teruo
AU - Kim, Sung Wan
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1991/10
Y1 - 1991/10
N2 - The crosslinked polymer, poly(2-acrylamido-2-methylpropane sulfonic acid-co-n-butylmethacrylate) [poly (AMPS/BMA)], was synthesized to study the effect of electric current on solute release. Edrophonium chloride, a positively charged solute was released in an on-off pattern from a poly(AMPS/BMA) monolithic device with electric stimulus. The on-off release mechanism of the positively charged solute was explained as an ion exchange between positive solute and hydroxonium ion, followed by fast release of the exchanged solute from the gel. The fast release was attributed to the electrostatic force, squeezing effect and the electro-osmosis of the gel. However, the release of neutral solute hydrocortisone was controlled by diffusion mechanism affected by swelling and deswelling of the gel.
AB - The crosslinked polymer, poly(2-acrylamido-2-methylpropane sulfonic acid-co-n-butylmethacrylate) [poly (AMPS/BMA)], was synthesized to study the effect of electric current on solute release. Edrophonium chloride, a positively charged solute was released in an on-off pattern from a poly(AMPS/BMA) monolithic device with electric stimulus. The on-off release mechanism of the positively charged solute was explained as an ion exchange between positive solute and hydroxonium ion, followed by fast release of the exchanged solute from the gel. The fast release was attributed to the electrostatic force, squeezing effect and the electro-osmosis of the gel. However, the release of neutral solute hydrocortisone was controlled by diffusion mechanism affected by swelling and deswelling of the gel.
KW - Drug delivery systems
KW - Ion exchange
KW - On-off switching release
KW - Polyelectrolytes
KW - Stimuli sensitive polymer
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U2 - 10.1016/0168-3659(91)90054-H
DO - 10.1016/0168-3659(91)90054-H
M3 - Article
AN - SCOPUS:0026004652
SN - 0168-3659
VL - 17
SP - 149-153,156
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 2
ER -