Drug release from electric current sensitive polymers

Ick Chan Kwon; You Han Bae; Teruo Okano; Sung Wan Kim

doi:10.1016/0168-3659(91)90054-H

Drug release from electric current sensitive polymers

Ick Chan Kwon, You Han Bae, Teruo Okano, Sung Wan Kim

Research output: Contribution to journal › Article › peer-review

123 Citations (Scopus)

Abstract

The crosslinked polymer, poly(2-acrylamido-2-methylpropane sulfonic acid-co-n-butylmethacrylate) [poly (AMPS/BMA)], was synthesized to study the effect of electric current on solute release. Edrophonium chloride, a positively charged solute was released in an on-off pattern from a poly(AMPS/BMA) monolithic device with electric stimulus. The on-off release mechanism of the positively charged solute was explained as an ion exchange between positive solute and hydroxonium ion, followed by fast release of the exchanged solute from the gel. The fast release was attributed to the electrostatic force, squeezing effect and the electro-osmosis of the gel. However, the release of neutral solute hydrocortisone was controlled by diffusion mechanism affected by swelling and deswelling of the gel.

Original language	English
Pages (from-to)	149-153,156
Journal	Journal of Controlled Release
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/0168-3659(91)90054-H
Publication status	Published - 1991 Oct

Keywords

Drug delivery systems
Ion exchange
On-off switching release
Polyelectrolytes
Stimuli sensitive polymer

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/0168-3659(91)90054-H

Cite this

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title = "Drug release from electric current sensitive polymers",

abstract = "The crosslinked polymer, poly(2-acrylamido-2-methylpropane sulfonic acid-co-n-butylmethacrylate) [poly (AMPS/BMA)], was synthesized to study the effect of electric current on solute release. Edrophonium chloride, a positively charged solute was released in an on-off pattern from a poly(AMPS/BMA) monolithic device with electric stimulus. The on-off release mechanism of the positively charged solute was explained as an ion exchange between positive solute and hydroxonium ion, followed by fast release of the exchanged solute from the gel. The fast release was attributed to the electrostatic force, squeezing effect and the electro-osmosis of the gel. However, the release of neutral solute hydrocortisone was controlled by diffusion mechanism affected by swelling and deswelling of the gel.",

keywords = "Drug delivery systems, Ion exchange, On-off switching release, Polyelectrolytes, Stimuli sensitive polymer",

author = "Kwon, {Ick Chan} and Bae, {You Han} and Teruo Okano and Kim, {Sung Wan}",

year = "1991",

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TY - JOUR

T1 - Drug release from electric current sensitive polymers

AU - Kwon, Ick Chan

AU - Bae, You Han

AU - Okano, Teruo

AU - Kim, Sung Wan

PY - 1991/10

Y1 - 1991/10

N2 - The crosslinked polymer, poly(2-acrylamido-2-methylpropane sulfonic acid-co-n-butylmethacrylate) [poly (AMPS/BMA)], was synthesized to study the effect of electric current on solute release. Edrophonium chloride, a positively charged solute was released in an on-off pattern from a poly(AMPS/BMA) monolithic device with electric stimulus. The on-off release mechanism of the positively charged solute was explained as an ion exchange between positive solute and hydroxonium ion, followed by fast release of the exchanged solute from the gel. The fast release was attributed to the electrostatic force, squeezing effect and the electro-osmosis of the gel. However, the release of neutral solute hydrocortisone was controlled by diffusion mechanism affected by swelling and deswelling of the gel.

AB - The crosslinked polymer, poly(2-acrylamido-2-methylpropane sulfonic acid-co-n-butylmethacrylate) [poly (AMPS/BMA)], was synthesized to study the effect of electric current on solute release. Edrophonium chloride, a positively charged solute was released in an on-off pattern from a poly(AMPS/BMA) monolithic device with electric stimulus. The on-off release mechanism of the positively charged solute was explained as an ion exchange between positive solute and hydroxonium ion, followed by fast release of the exchanged solute from the gel. The fast release was attributed to the electrostatic force, squeezing effect and the electro-osmosis of the gel. However, the release of neutral solute hydrocortisone was controlled by diffusion mechanism affected by swelling and deswelling of the gel.

KW - Drug delivery systems

KW - Ion exchange

KW - On-off switching release

KW - Polyelectrolytes

KW - Stimuli sensitive polymer

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U2 - 10.1016/0168-3659(91)90054-H

DO - 10.1016/0168-3659(91)90054-H

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SN - 0168-3659

VL - 17

SP - 149-153,156

JO - Journal of Controlled Release

JF - Journal of Controlled Release

IS - 2

ER -

Drug release from electric current sensitive polymers

Abstract

Keywords

ASJC Scopus subject areas

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