Dual-functional fluorescent molecular rotor for endoplasmic reticulum microviscosity imaging during reticulophagy

Ying He; Jinwoo Shin; Wanjun Gong; Pintu Das; Jinghan Qu; Zhigang Yang; Wufan Liu; Chulhun Kang; Junle Qu; Jong Seung Kim

doi:10.1039/c9cc00300b

Dual-functional fluorescent molecular rotor for endoplasmic reticulum microviscosity imaging during reticulophagy

Ying He, Jinwoo Shin, Wanjun Gong, Pintu Das, Jinghan Qu, Zhigang Yang, Wufan Liu, Chulhun Kang, Junle Qu, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

The microviscosity change associated with reticulophagy is an important component for studying endoplasmic reticulum (ER) stress disorders. Here, a BODIPY-arsenicate conjugate 1-based fluorescent molecular rotor was designed to covalently bind vicinal dithiol-containing proteins in the ER, exhibiting a bifunction of reticulophagy initiation and microviscosity evaluation. Therefore, we could quantify the local viscosity changes during reticulophagy based on the fluorescence lifetime changes of probe 1.

Original language	English
Pages (from-to)	2453-2456
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	17
DOIs	https://doi.org/10.1039/c9cc00300b
Publication status	Published - 2019

Bibliographical note

Publisher Copyright:
© 2019 The Royal Society of Chemistry.

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c9cc00300b

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title = "Dual-functional fluorescent molecular rotor for endoplasmic reticulum microviscosity imaging during reticulophagy",

abstract = "The microviscosity change associated with reticulophagy is an important component for studying endoplasmic reticulum (ER) stress disorders. Here, a BODIPY-arsenicate conjugate 1-based fluorescent molecular rotor was designed to covalently bind vicinal dithiol-containing proteins in the ER, exhibiting a bifunction of reticulophagy initiation and microviscosity evaluation. Therefore, we could quantify the local viscosity changes during reticulophagy based on the fluorescence lifetime changes of probe 1.",

author = "Ying He and Jinwoo Shin and Wanjun Gong and Pintu Das and Jinghan Qu and Zhigang Yang and Wufan Liu and Chulhun Kang and Junle Qu and Kim, {Jong Seung}",

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language = "English",

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T1 - Dual-functional fluorescent molecular rotor for endoplasmic reticulum microviscosity imaging during reticulophagy

AU - He, Ying

AU - Shin, Jinwoo

AU - Gong, Wanjun

AU - Das, Pintu

AU - Qu, Jinghan

AU - Yang, Zhigang

AU - Liu, Wufan

AU - Kang, Chulhun

AU - Qu, Junle

AU - Kim, Jong Seung

PY - 2019

Y1 - 2019

N2 - The microviscosity change associated with reticulophagy is an important component for studying endoplasmic reticulum (ER) stress disorders. Here, a BODIPY-arsenicate conjugate 1-based fluorescent molecular rotor was designed to covalently bind vicinal dithiol-containing proteins in the ER, exhibiting a bifunction of reticulophagy initiation and microviscosity evaluation. Therefore, we could quantify the local viscosity changes during reticulophagy based on the fluorescence lifetime changes of probe 1.

AB - The microviscosity change associated with reticulophagy is an important component for studying endoplasmic reticulum (ER) stress disorders. Here, a BODIPY-arsenicate conjugate 1-based fluorescent molecular rotor was designed to covalently bind vicinal dithiol-containing proteins in the ER, exhibiting a bifunction of reticulophagy initiation and microviscosity evaluation. Therefore, we could quantify the local viscosity changes during reticulophagy based on the fluorescence lifetime changes of probe 1.

UR - http://www.scopus.com/inward/record.url?scp=85061973737&partnerID=8YFLogxK

U2 - 10.1039/c9cc00300b

DO - 10.1039/c9cc00300b

M3 - Article

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AN - SCOPUS:85061973737

SN - 1359-7345

VL - 55

SP - 2453

EP - 2456

JO - Chemical Communications

JF - Chemical Communications

IS - 17

ER -

Dual-functional fluorescent molecular rotor for endoplasmic reticulum microviscosity imaging during reticulophagy

Abstract

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ASJC Scopus subject areas

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