Dual-functional fluorescent molecular rotor for endoplasmic reticulum microviscosity imaging during reticulophagy

Ying He, Jinwoo Shin, Wanjun Gong, Pintu Das, Jinghan Qu, Zhigang Yang, Wufan Liu, Chulhun Kang, Junle Qu, Jong Seung Kim

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

The microviscosity change associated with reticulophagy is an important component for studying endoplasmic reticulum (ER) stress disorders. Here, a BODIPY-arsenicate conjugate 1-based fluorescent molecular rotor was designed to covalently bind vicinal dithiol-containing proteins in the ER, exhibiting a bifunction of reticulophagy initiation and microviscosity evaluation. Therefore, we could quantify the local viscosity changes during reticulophagy based on the fluorescence lifetime changes of probe 1.

Original languageEnglish
Pages (from-to)2453-2456
Number of pages4
JournalChemical Communications
Volume55
Issue number17
DOIs
Publication statusPublished - 2019

Bibliographical note

Funding Information:
This work has been partially supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (CRI project no. 2018R1A3B1052702, JSK) and the National Natural Science Foundation of China (61525503/61875131/61620106016/61835009/81727804).

Funding Information:
This work has been partially supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (CRI project no. 2018R1A3B1052702, JSK) and the National Natural Science Foundation of China (61525503/ 61875131/61620106016/61835009/81727804); the Basic Research Program of China (2015CB352005); Guangdong Natural Science Foundation Innovation Team (2014A030312008); and Shenzhen Basic Research Project (JCYJ20170818100931714/JCYJ2015093 0104948169).

Publisher Copyright:
© 2019 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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