@article{8a47f92b2035451ea858c65a346c0410,
title = "Dual Leucine Zipper Kinase Is Required for Retrograde Injury Signaling and Axonal Regeneration",
abstract = "Here we demonstrate that the dual leucine zipper kinase (DLK) promotes robust regeneration of peripheral axons after nerve injury in mice. Peripheral axon regeneration is accelerated by prior injury; however, DLK KO neurons do not respond to a preconditioning lesion with enhanced regeneration in vivo or in vitro. Assays for activation of transcription factors in injury-induced proregenerative pathways reveal that loss of DLK abolishes upregulation of p-STAT3 and p-cJun in the cell body after axonal injury. DLK is not required for the phosphorylation of STAT3 at the site of nerve injury but is necessary for retrograde transport of p-STAT3 to the cell body. These data demonstrate that DLK enhances regeneration by promoting a retrograde injury signal that is required for the activation of the neuronal proregenerative program.",
author = "Shin, {Jung Eun} and Yongcheol Cho and Bogdan Beirowski and Jeffrey Milbrandt and Valeria Cavalli and Aaron DiAntonio",
note = "Funding Information: We are grateful to Dr. Joshua Sanes and Dr. Lawrence B. Holzman for sharing reagents. We thank the members of the DiAntonio, Cavalli, and Milbrandt laboratories for helpful discussions. We also appreciate Dr. Namiko Abe, Dr. Santosh Kale, Alice Tong, and Dennis Oakley for their advice and Sylvia Johnson for her technical assistance. The work was supported by the NIH Neuroscience Blueprint Center Core Grant P30 NS057105 to Washington University, the HOPE Center for Neurological Disorders, European Molecular Biology Organization (EMBO) long-term fellowship (B.B.), Edward Mallinckrodt, Jr. Foundation (V.C.), NIH grants NS060709 (V.C.), AG13730 (J.M.), and NS070053 and NS065053 (J.M. and A.D.). A.D., J.E.S., and Washington University may receive income based on a license by the university to Novus Biologicals. ",
year = "2012",
month = jun,
day = "21",
doi = "10.1016/j.neuron.2012.04.028",
language = "English",
volume = "74",
pages = "1015--1022",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "6",
}