Dual temperature and thiol-responsive POEOMA-multisegmented polydisulfides: Synthesis and thermoresponsive properties

Qian Zhang; Seung Man Noh; Joon Hyun Nam; Hyun Wook Jung; Jong Myung Park; Jung Kwon Oh

doi:10.1002/marc.201200289

Dual temperature and thiol-responsive POEOMA-multisegmented polydisulfides: Synthesis and thermoresponsive properties

Qian Zhang, Seung Man Noh, Joon Hyun Nam, Hyun Wook Jung, Jong Myung Park, Jung Kwon Oh

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

New thermoresponsive polydisulfides of POEOMA multiblocks linked with disulfide bonds having redox-responsive properties are reported. These POEOMA-multisegmented polydisulfides were synthesized by a new method employing a combined RAFT/aminolysis and reversible thiol-disulfide redox reaction that centers on the synthesis of new disulfide-labeled difunctional RAFT agent. RAFT polymerization proceeded in living fashion, yielding well-defined POEOMA copolymers with middle disulfides and terminal RAFT species. They were then used as precursors for thiol-disulfide polyexchange induced by aminolysis and reductive reaction followed by oxidation: these polydisulfides with different molecular weights and end groups ex hibited tunable thermoresponsive properties and thiol-responsive degradation.

Original language	English
Pages (from-to)	1528-1534
Number of pages	7
Journal	Macromolecular Rapid Communications
Volume	33
Issue number	18
DOIs	https://doi.org/10.1002/marc.201200289
Publication status	Published - 2012 Sept 26

Keywords

LCST
RAFT
aminolysis
disulfide-thiol exchange
polydisulfides
stimuli-sensitive polymers

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1002/marc.201200289

Cite this

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title = "Dual temperature and thiol-responsive POEOMA-multisegmented polydisulfides: Synthesis and thermoresponsive properties",

abstract = "New thermoresponsive polydisulfides of POEOMA multiblocks linked with disulfide bonds having redox-responsive properties are reported. These POEOMA-multisegmented polydisulfides were synthesized by a new method employing a combined RAFT/aminolysis and reversible thiol-disulfide redox reaction that centers on the synthesis of new disulfide-labeled difunctional RAFT agent. RAFT polymerization proceeded in living fashion, yielding well-defined POEOMA copolymers with middle disulfides and terminal RAFT species. They were then used as precursors for thiol-disulfide polyexchange induced by aminolysis and reductive reaction followed by oxidation: these polydisulfides with different molecular weights and end groups ex hibited tunable thermoresponsive properties and thiol-responsive degradation.",

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T2 - Synthesis and thermoresponsive properties

AU - Zhang, Qian

AU - Noh, Seung Man

AU - Nam, Joon Hyun

AU - Jung, Hyun Wook

AU - Park, Jong Myung

AU - Oh, Jung Kwon

PY - 2012/9/26

Y1 - 2012/9/26

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AB - New thermoresponsive polydisulfides of POEOMA multiblocks linked with disulfide bonds having redox-responsive properties are reported. These POEOMA-multisegmented polydisulfides were synthesized by a new method employing a combined RAFT/aminolysis and reversible thiol-disulfide redox reaction that centers on the synthesis of new disulfide-labeled difunctional RAFT agent. RAFT polymerization proceeded in living fashion, yielding well-defined POEOMA copolymers with middle disulfides and terminal RAFT species. They were then used as precursors for thiol-disulfide polyexchange induced by aminolysis and reductive reaction followed by oxidation: these polydisulfides with different molecular weights and end groups ex hibited tunable thermoresponsive properties and thiol-responsive degradation.

KW - LCST

KW - RAFT

KW - aminolysis

KW - disulfide-thiol exchange

KW - polydisulfides

KW - stimuli-sensitive polymers

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Dual temperature and thiol-responsive POEOMA-multisegmented polydisulfides: Synthesis and thermoresponsive properties

Abstract

Keywords

ASJC Scopus subject areas

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