@article{895e9a0f2bb540eea0dd21f1071c9bde,
title = "Durable and Fatigue-Resistant Soft Peripheral Neuroprosthetics for In Vivo Bidirectional Signaling",
abstract = "Soft neuroprosthetics that monitor signals from sensory neurons and deliver motor information can potentially replace damaged nerves. However, achieving long-term stability of devices interfacing peripheral nerves is challenging, since dynamic mechanical deformations in peripheral nerves cause material degradation in devices. Here, a durable and fatigue-resistant soft neuroprosthetic device is reported for bidirectional signaling on peripheral nerves. The neuroprosthetic device is made of a nanocomposite of gold nanoshell (AuNS)-coated silver (Ag) flakes dispersed in a tough, stretchable, and self-healing polymer (SHP). The dynamic self-healing property of the nanocomposite allows the percolation network of AuNS-coated flakes to rebuild after degradation. Therefore, its degraded electrical and mechanical performance by repetitive, irregular, and intense deformations at the device–nerve interface can be spontaneously self-recovered. When the device is implanted on a rat sciatic nerve, stable bidirectional signaling is obtained for over 5 weeks. Neural signals collected from a live walking rat using these neuroprosthetics are analyzed by a deep neural network to predict the joint position precisely. This result demonstrates that durable soft neuroprosthetics can facilitate collection and analysis of large-sized in vivo data for solving challenges in neurological disorders.",
keywords = "conducting nanocomposites, fatigue-resistant nanocomposites, in vivo bidirectional signaling, soft peripheral neuroprosthetics",
author = "Hyunseon Seo and Han, {Sang Ihn} and Song, {Kang Il} and Duhwan Seong and Kyungwoo Lee and Kim, {Sun Hong} and Taesung Park and Koo, {Ja Hoon} and Mikyung Shin and Baac, {Hyoung Won} and Park, {Ok Kyu} and Oh, {Soong Ju} and Han, {Hyung Seop} and Hojeong Jeon and Kim, {Yu Chan} and Kim, {Dae Hyeong} and Taeghwan Hyeon and Donghee Son",
note = "Funding Information: This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Science and ICT (MSIT)) (Grant No. 2020R1C1C1005567) and Institute of Information & Communications Technology Planning & Evaluation (IITP) grant funded by the Korea government (MSIT) (Grant No. 2020-0-00261, development of low-power/low-delay/self-power suppliable radio-frequency simultaneous information and power-transfer system and stretchable electronic epineurium for wireless nerve bypass implementation). This research was also supported by the MSIT, Korea, under the ICT Creative Consilience program (IITP-2020-0-01821) supervised by the IITP. This research was also supported by Institute for Basic Science (IBS-R006-D1, IBS-R006-A1, and IBS-R015-D1) and SMC-SKKU Future Convergence Research Program grant. This work was also supported by the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, and the Ministry of Food and Drug Safety) (Project No: 202012D28). All animal experiments were performed and handled in accordance with the regulation of the Institutional Animal Care and Use Committee of the Korea Institute of Science and Technology (Approval No. 2019-111). All experimental procedures were performed according to the Guide for the Care and Use of Laboratory Animals. Publisher Copyright: {\textcopyright} 2021 Wiley-VCH GmbH",
year = "2021",
month = may,
day = "20",
doi = "10.1002/adma.202007346",
language = "English",
volume = "33",
journal = "Advanced Materials",
issn = "0935-9648",
publisher = "Wiley-VCH Verlag",
number = "20",
}