Dynamic changes in the bridging collaterals of the basal ganglia circuitry control stress-related behaviors in mice

Young Lee, Na Eun Han, Wonju Kim, Jae Gon Kim, In Bum Lee, Su Jeong Choi, Heejung Chun, Misun Seo, Changjoon Lee, Hae Young Koh, Joung Hun Kim, Ja Hyun Baik, Mark F. Bear, Se Young Choi, Bong June Yoon

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The basal ganglia network has been implicated in the control of adaptive behavior, possibly by integrating motor learning and motivational processes. Both positive and negative reinforcement appear to shape our behavioral adaptation by modulating the function of the basal ganglia. Here, we examined a transgenic mouse line (G2CT) in which synaptic transmissions onto the medium spiny neurons (MSNs) of the basal ganglia are depressed. We found that the level of collaterals from direct pathway MSNs in the external segment of the globus pallidus (GPe) (‘bridging collaterals’) was decreased in these mice, and this was accompanied by behavioral inhibition under stress. Furthermore, additional manipulations that could further decrease or restore the level of the bridging collaterals resulted in an increase in behavioral inhibition or active behavior in the G2CT mice, respectively. Collectively, our data indicate that the striatum of the basal ganglia network integrates negative emotions and controls appropriate coping responses in which the bridging collateral connections in the GPe play a critical regulatory role.

Original languageEnglish
Pages (from-to)360-372
Number of pages13
JournalMolecules and cells
Issue number4
Publication statusPublished - 2020

Bibliographical note

Funding Information:
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, & Future Planning of the Republic of Korea (NRF-2017R1A2B4007288) and a Korea University research grant to BJY and in part by the KIST Institutional Program (project No. 2E26640) to HYK. We thank Sooji Kim and Sangheon Ji for technical assistance.

Publisher Copyright:
© The Korean Society for Molecular and Cellular Biology. All rights reserved.


  • Basal ganglia
  • Bridging collaterals
  • Globus pallidus
  • Stress

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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