Dynamic metallization of spherical DNA via conformational transition into gold nanostructures with controlled sizes and shapes

Won Kyu Lee; Kihun Kwon; Yeonho Choi; Jae-Seung Lee

doi:10.1016/j.jcis.2021.02.134

Dynamic metallization of spherical DNA via conformational transition into gold nanostructures with controlled sizes and shapes

Won Kyu Lee, Kihun Kwon, Yeonho Choi, Jae-Seung Lee

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Despite the reversible condensation properties of DNA, DNA metallization during controlled conformational transitions has been rarely investigated. We perform dynamic metallization of spherically condensed DNA nanoparticles (DNA NPs) via a globule-to-coil transition. A positively charged new Au³⁺ reagent is prepared via ligand-exchange of conventional complex Au³⁺ ions, which was used to synthesize spherically condensed DNA NPs simply based on the fundamental electrostatic and coordinative interactions between DNA and Au³⁺ ions. Interestingly, the size of the Au³⁺-condensed DNA NPs (Au³⁺-DNA NPs) and the type of reducing agents lead to the formation of different Au nanostructures with unprecedented morphologies (cracked NPs, bowl-shaped NPs, and small NPs), owing to the controlled conformational changes in the Au³⁺-DNA NPs during metallization. The condensed DNA NPs play significant roles for Au nanostructures as (1) the dynamic template for the synthesis, (2) the reservoir and supply of Au³⁺ for the growth, and (3) the surface stabilizer. The synthesized Au nanostructures are remarkably stable against high ionic strength and exhibit catalytic activities and excellent SERS properties. This is the first study on the morphological control and concomitant dynamic metallization of spherically condensed DNA, proposing new synthetic routes for bioinorganic nanomaterials.

Original language	English
Pages (from-to)	160-172
Number of pages	13
Journal	Journal of Colloid and Interface Science
Volume	594
DOIs	https://doi.org/10.1016/j.jcis.2021.02.134
Publication status	Published - 2021 Jul 15

Bibliographical note

Funding Information:
This study was supported by BK21 FOUR Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 4199990514635 ) and by the NRF grant funded by the Ministry of Science and ICT (NRF-2018R1A1A1A05079384, NRF-2016R1A5A1010148 and NRF-2021R1A2C1012917). The TEM images and ICP–MS data were obtained at the Seoul Center of the Korea Basic Science Institute (KBSI, Republic of Korea) and the XPS spectra were obtained at the Busan center of the KBSI.

Funding Information:
This study was supported by BK21 FOUR Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (4199990514635) and by the NRF grant funded by the Ministry of Science and ICT (NRF-2018R1A1A1A05079384, NRF-2016R1A5A1010148 and NRF-2021R1A2C1012917). The TEM images and ICP–MS data were obtained at the Seoul Center of the Korea Basic Science Institute (KBSI, Republic of Korea) and the XPS spectra were obtained at the Busan center of the KBSI.

Publisher Copyright:
© 2021 Elsevier Inc.

Keywords

Au
Catalysis
Conformation transition
DNA template
Dynamic metallization
Surface-enhanced Raman spectroscopy

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Surfaces, Coatings and Films
Colloid and Surface Chemistry

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10.1016/j.jcis.2021.02.134

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@article{eab690ad379e485c8a76a6f3a47b5b5c,

title = "Dynamic metallization of spherical DNA via conformational transition into gold nanostructures with controlled sizes and shapes",

abstract = "Despite the reversible condensation properties of DNA, DNA metallization during controlled conformational transitions has been rarely investigated. We perform dynamic metallization of spherically condensed DNA nanoparticles (DNA NPs) via a globule-to-coil transition. A positively charged new Au3+ reagent is prepared via ligand-exchange of conventional complex Au3+ ions, which was used to synthesize spherically condensed DNA NPs simply based on the fundamental electrostatic and coordinative interactions between DNA and Au3+ ions. Interestingly, the size of the Au3+-condensed DNA NPs (Au3+-DNA NPs) and the type of reducing agents lead to the formation of different Au nanostructures with unprecedented morphologies (cracked NPs, bowl-shaped NPs, and small NPs), owing to the controlled conformational changes in the Au3+-DNA NPs during metallization. The condensed DNA NPs play significant roles for Au nanostructures as (1) the dynamic template for the synthesis, (2) the reservoir and supply of Au3+ for the growth, and (3) the surface stabilizer. The synthesized Au nanostructures are remarkably stable against high ionic strength and exhibit catalytic activities and excellent SERS properties. This is the first study on the morphological control and concomitant dynamic metallization of spherically condensed DNA, proposing new synthetic routes for bioinorganic nanomaterials.",

keywords = "Au, Catalysis, Conformation transition, DNA template, Dynamic metallization, Surface-enhanced Raman spectroscopy",

author = "Lee, {Won Kyu} and Kihun Kwon and Yeonho Choi and Jae-Seung Lee",

note = "Funding Information: This study was supported by BK21 FOUR Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 4199990514635 ) and by the NRF grant funded by the Ministry of Science and ICT (NRF-2018R1A1A1A05079384, NRF-2016R1A5A1010148 and NRF-2021R1A2C1012917). The TEM images and ICP–MS data were obtained at the Seoul Center of the Korea Basic Science Institute (KBSI, Republic of Korea) and the XPS spectra were obtained at the Busan center of the KBSI. Funding Information: This study was supported by BK21 FOUR Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (4199990514635) and by the NRF grant funded by the Ministry of Science and ICT (NRF-2018R1A1A1A05079384, NRF-2016R1A5A1010148 and NRF-2021R1A2C1012917). The TEM images and ICP–MS data were obtained at the Seoul Center of the Korea Basic Science Institute (KBSI, Republic of Korea) and the XPS spectra were obtained at the Busan center of the KBSI. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

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day = "15",

doi = "10.1016/j.jcis.2021.02.134",

language = "English",

volume = "594",

pages = "160--172",

journal = "Journal of Colloid and Interface Science",

issn = "0021-9797",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Dynamic metallization of spherical DNA via conformational transition into gold nanostructures with controlled sizes and shapes

AU - Lee, Won Kyu

AU - Kwon, Kihun

AU - Choi, Yeonho

AU - Lee, Jae-Seung

N1 - Funding Information: This study was supported by BK21 FOUR Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 4199990514635 ) and by the NRF grant funded by the Ministry of Science and ICT (NRF-2018R1A1A1A05079384, NRF-2016R1A5A1010148 and NRF-2021R1A2C1012917). The TEM images and ICP–MS data were obtained at the Seoul Center of the Korea Basic Science Institute (KBSI, Republic of Korea) and the XPS spectra were obtained at the Busan center of the KBSI. Funding Information: This study was supported by BK21 FOUR Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (4199990514635) and by the NRF grant funded by the Ministry of Science and ICT (NRF-2018R1A1A1A05079384, NRF-2016R1A5A1010148 and NRF-2021R1A2C1012917). The TEM images and ICP–MS data were obtained at the Seoul Center of the Korea Basic Science Institute (KBSI, Republic of Korea) and the XPS spectra were obtained at the Busan center of the KBSI. Publisher Copyright: © 2021 Elsevier Inc.

PY - 2021/7/15

Y1 - 2021/7/15

N2 - Despite the reversible condensation properties of DNA, DNA metallization during controlled conformational transitions has been rarely investigated. We perform dynamic metallization of spherically condensed DNA nanoparticles (DNA NPs) via a globule-to-coil transition. A positively charged new Au3+ reagent is prepared via ligand-exchange of conventional complex Au3+ ions, which was used to synthesize spherically condensed DNA NPs simply based on the fundamental electrostatic and coordinative interactions between DNA and Au3+ ions. Interestingly, the size of the Au3+-condensed DNA NPs (Au3+-DNA NPs) and the type of reducing agents lead to the formation of different Au nanostructures with unprecedented morphologies (cracked NPs, bowl-shaped NPs, and small NPs), owing to the controlled conformational changes in the Au3+-DNA NPs during metallization. The condensed DNA NPs play significant roles for Au nanostructures as (1) the dynamic template for the synthesis, (2) the reservoir and supply of Au3+ for the growth, and (3) the surface stabilizer. The synthesized Au nanostructures are remarkably stable against high ionic strength and exhibit catalytic activities and excellent SERS properties. This is the first study on the morphological control and concomitant dynamic metallization of spherically condensed DNA, proposing new synthetic routes for bioinorganic nanomaterials.

AB - Despite the reversible condensation properties of DNA, DNA metallization during controlled conformational transitions has been rarely investigated. We perform dynamic metallization of spherically condensed DNA nanoparticles (DNA NPs) via a globule-to-coil transition. A positively charged new Au3+ reagent is prepared via ligand-exchange of conventional complex Au3+ ions, which was used to synthesize spherically condensed DNA NPs simply based on the fundamental electrostatic and coordinative interactions between DNA and Au3+ ions. Interestingly, the size of the Au3+-condensed DNA NPs (Au3+-DNA NPs) and the type of reducing agents lead to the formation of different Au nanostructures with unprecedented morphologies (cracked NPs, bowl-shaped NPs, and small NPs), owing to the controlled conformational changes in the Au3+-DNA NPs during metallization. The condensed DNA NPs play significant roles for Au nanostructures as (1) the dynamic template for the synthesis, (2) the reservoir and supply of Au3+ for the growth, and (3) the surface stabilizer. The synthesized Au nanostructures are remarkably stable against high ionic strength and exhibit catalytic activities and excellent SERS properties. This is the first study on the morphological control and concomitant dynamic metallization of spherically condensed DNA, proposing new synthetic routes for bioinorganic nanomaterials.

KW - Au

KW - Catalysis

KW - Conformation transition

KW - DNA template

KW - Dynamic metallization

KW - Surface-enhanced Raman spectroscopy

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U2 - 10.1016/j.jcis.2021.02.134

DO - 10.1016/j.jcis.2021.02.134

M3 - Article

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AN - SCOPUS:85102883862

SN - 0021-9797

VL - 594

SP - 160

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JO - Journal of Colloid and Interface Science

JF - Journal of Colloid and Interface Science

ER -

Dynamic metallization of spherical DNA via conformational transition into gold nanostructures with controlled sizes and shapes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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