Dynamical response of nanomechanical resonators to biomolecular interactions

Kilho Eom, Tae Yun Kwon, Dae Sung Yoon, Hong Lim Lee, Tae Song Kim

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30 Citations (Scopus)


We studied the dynamical response of a nanomechanical resonator to biomolecular (e.g., DNA) adsorptions on a resonator's surface by using theoretical model, which considers the Hamiltonian H such that the potential energy consists of elastic bending energy of a resonator and the potential energy for biomolecular interactions. It was shown that the resonant frequency shift for a resonator due to biomolecular adsorption depends on not only the mass of adsorbed biomolecules but also the biomolecular interactions. Specifically, for double-stranded DNA adsorption on a resonator's surface, the resonant frequency shift is also dependent on the ionic strength of a solvent, implying the role of biomolecular interactions on the dynamic behavior of a resonator. This indicates that nanomechanical resonators may enable one to quantify the biomolecular mass, implying the enumeration of biomolecules, as well as gain insight into intermolecular interactions between adsorbed biomolecules on the surface.

Original languageEnglish
Article number113408
JournalPhysical Review B - Condensed Matter and Materials Physics
Issue number11
Publication statusPublished - 2007 Sept 19
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics


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