E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells

Jung Ok Lee; Soo Kyung Lee; Nami Kim; Ji Hae Kim; Ga Young You; Ji Wook Moon; Sha Jie; Su Jin Kim; Yong Woo Lee; Ho Jin Kang; Yongchul Lim; Sun Hwa Park; Hyeon Soo Kim

doi:10.1074/jbc.M112.406009

E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells

Jung Ok Lee, Soo Kyung Lee, Nami Kim, Ji Hae Kim, Ga Young You, Ji Wook Moon, Sha Jie, Su Jin Kim, Yong Woo Lee, Ho Jin Kang, Yongchul Lim, Sun Hwa Park, Hyeon Soo Kim

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Background: The role of the ubiquitin-proteasome pathway under high glucose conditions is unclear. Results: AMPKα2 interacts with WWP1, and its expression is down-regulated by the ubiquitin proteasome pathway in high glucose culture conditions in C2C12 cells. Conclusion: WWP1 down-regulates AMPKα2 expression through direct interaction in high glucose culture conditions of skeletal muscle C2C12 cells. Significance: The ubiquitin proteasome pathway may involve high glucose-induced AMPKa2 down-regulation.

Original language	English
Pages (from-to)	4673-4680
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	288
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M112.406009
Publication status	Published - 2013 Feb 15
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells",

abstract = "Background: The role of the ubiquitin-proteasome pathway under high glucose conditions is unclear. Results: AMPKα2 interacts with WWP1, and its expression is down-regulated by the ubiquitin proteasome pathway in high glucose culture conditions in C2C12 cells. Conclusion: WWP1 down-regulates AMPKα2 expression through direct interaction in high glucose culture conditions of skeletal muscle C2C12 cells. Significance: The ubiquitin proteasome pathway may involve high glucose-induced AMPKa2 down-regulation.",

author = "Lee, {Jung Ok} and Lee, {Soo Kyung} and Nami Kim and Kim, {Ji Hae} and You, {Ga Young} and Moon, {Ji Wook} and Sha Jie and Kim, {Su Jin} and Lee, {Yong Woo} and Kang, {Ho Jin} and Yongchul Lim and Park, {Sun Hwa} and Kim, {Hyeon Soo}",

year = "2013",

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doi = "10.1074/jbc.M112.406009",

language = "English",

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journal = "Journal of Biological Chemistry",

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T1 - E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells

AU - Lee, Jung Ok

AU - Lee, Soo Kyung

AU - Kim, Nami

AU - Kim, Ji Hae

AU - You, Ga Young

AU - Moon, Ji Wook

AU - Jie, Sha

AU - Kim, Su Jin

AU - Lee, Yong Woo

AU - Kang, Ho Jin

AU - Lim, Yongchul

AU - Park, Sun Hwa

AU - Kim, Hyeon Soo

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Background: The role of the ubiquitin-proteasome pathway under high glucose conditions is unclear. Results: AMPKα2 interacts with WWP1, and its expression is down-regulated by the ubiquitin proteasome pathway in high glucose culture conditions in C2C12 cells. Conclusion: WWP1 down-regulates AMPKα2 expression through direct interaction in high glucose culture conditions of skeletal muscle C2C12 cells. Significance: The ubiquitin proteasome pathway may involve high glucose-induced AMPKa2 down-regulation.

AB - Background: The role of the ubiquitin-proteasome pathway under high glucose conditions is unclear. Results: AMPKα2 interacts with WWP1, and its expression is down-regulated by the ubiquitin proteasome pathway in high glucose culture conditions in C2C12 cells. Conclusion: WWP1 down-regulates AMPKα2 expression through direct interaction in high glucose culture conditions of skeletal muscle C2C12 cells. Significance: The ubiquitin proteasome pathway may involve high glucose-induced AMPKa2 down-regulation.

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DO - 10.1074/jbc.M112.406009

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AN - SCOPUS:84874077399

SN - 0021-9258

VL - 288

SP - 4673

EP - 4680

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 7

ER -

E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells

Abstract

ASJC Scopus subject areas

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