Early-Life Nutrition and Cognitive Development: Imaging Approaches

Weili Lin, Kristine R. Baluyot, Manjiang Yao, Jian Yan, Li Wang, Gang Li, Brittany Howell, Jed T. Elison, Dinggang Shen

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Brain development in the first years of life is the most dynamic and perhaps the most important phase of brain maturation. While it is widely recognized that nutrition plays a key role in early brain development, particular nutrients will most likely differentially affect distinct aspects of brain development. The critical dosage windows and time frames for various nutrients at different stages of brain development are likely dissimilar. Therefore, efforts have been devoted to identifying potential associations between nutrients and early brain development. However, behavioral assessments are typically employed as the outcome measures, which are known to suffer from low sensitivity and the inability to provide neural substrates underlying brain functional maturation. In contrast, magnetic resonance imaging is capable of providing detailed anatomical and functional information - an ideal tool to characterize brain functional development and nutrition. Our team has developed strategies that enable imaging of typically developing children from birth to teens without sedation. Quantitative assessments of brain structural and functional development during the first years of life have been accomplished, which reveal important features of early brain development. These developed tools will most likely substantially enhance our ability to rigorously characterize the interplay between nutrients and early brain development.

Original languageEnglish
Pages (from-to)121-135
Number of pages15
JournalNestle Nutrition Institute Workshop Series
Volume90
DOIs
Publication statusPublished - 2019

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Early-Life Nutrition and Cognitive Development: Imaging Approaches'. Together they form a unique fingerprint.

Cite this