Abstract
We compared texture parameters of serial cranial ultrasound (cUS) images of periventricular leukomalacia (PVL) and normal periventricular echogenicity (PVE) in very preterm infants and evaluated the early predictive values of texture analysis (TA) for PVL. Ten individuals with PVL and 10 control individuals with PVE assessed with an initial cUS within 1 wk of birth and follow-up cUS at 2–3 and 4–6 wk of life were included. TA was performed on the region of interest of PVE at the parieto-occipital area on serial cUS. Opposite changes in variance were obtained between the first two cUS sessions in both groups (p = 0.017 in PVL and p = 0.005 in PVE). The variance-to-mean ratio (VMR) between the second and first cUS sessions differed (p = 0.016) and reliably stratified the groups (area under the receiver operating characteristic curve: 0.820, 95% confidence interval: 0.587–1.000, sensitivity: 100%, specificity: 60%). TA of serial cUS helps to predict PVL within 3 wk of life.
Original language | English |
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Pages (from-to) | 2658-2665 |
Number of pages | 8 |
Journal | Ultrasound in Medicine and Biology |
Volume | 45 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2019 Oct |
Bibliographical note
Publisher Copyright:© 2019 World Federation for Ultrasound in Medicine & Biology
Keywords
- Index of dispersion
- Periventricular leukomalacia
- Preterm infant
- Quantitative texture analysis
- Serial cranial ultrasound
- Variance
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Biophysics
- Acoustics and Ultrasonics