Early red blood cell abnormalities as a clinical variable in sepsis diagnosis

Eunji Ko, Jung Min Youn, Hyung Sun Park, Myeongjin Song, Kyung Hee Koh, Choon Hak Lim

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)


    BACKGROUND: Sepsis is a medical emergency during which early detection is closely associated with mortality. In sepsis, red blood cell (RBC) abnormalities have been reported. However, it is not known how early RBC abnormalities are expressed compared with various clinical manifestations used in sepsis-related organ failure assessment (SOFA). OBJECTIVE: Therefore, using a lipopolysaccharide (LPS)-induced sepsis model we investigated the clinical significance of RBC abnormalities as an early indicator in the detection of septic injury compared with clinical variables. METHODS: Sprague-Dawley rats received LPS (20 mg/kg) intraperitoneally. Aggregation indices (AIs) and aggregation half-time (T1/2), and elongation indices (EI max) were measured. Clinical data-related SOFA and lactate were measured at 2 h, 4 h, 8 h and 12 h after LPS injection. RESULTS: AIs increased at 4 h, and T1/2 decreased at 2 h after LPS injection. Platelet counts decreased at 4 h, and lactate increased at 2 h after LPS injection. AIs showed strong correlations with T1/2 and platelets, EI max increased at 2 h after LPS injection, while EI max had a positive correlation with lactate. CONCLUSIONS: RBC aggregation appears to be an early indicator of clinical deterioration in sepsis and may represent a diagnostic indicator in sepsis.

    Original languageEnglish
    Pages (from-to)355-363
    Number of pages9
    JournalClinical Hemorheology and Microcirculation
    Issue number3
    Publication statusPublished - 2018

    Bibliographical note

    Funding Information:
    This study was supported by Korea University grants and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (No. NRF-2015R1A2A2A01006734).

    Publisher Copyright:
    © 2018 - IOS Press and the authors. All rights reserved.


    • Red blood cell aggregation
    • red blood cell deformability
    • sepsis
    • sepsis-related organ failure assessment

    ASJC Scopus subject areas

    • Physiology
    • Hematology
    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)


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