Early statin use in ischemic stroke patients treated with recanalization therapy: Retrospective observational study

Jihoon Kang, Nayoung Kim, Tae Hwan Park, Oh Young Bang, Ji Sung Lee, Juneyoung Lee, Moon Ku Han, Seong Ho Park, Philip B. Gorelick, Hee Joon Bae

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Background: We aimed to determine whether early statin use following recanalization therapy improves the functional outcome of ischemic stroke. Methods: Using a prospective stroke registry database, we identified a consecutive 337 patients within 6 h of onset who had symptomatic stenosis or occlusion of major cerebral arteries and received recanalization therapy. Based on commencement of statin therapy, patients were categorized into administration on the first (D1, 13.4 %), second (D2, 20.8 %) and third day or later (D ≥ 3, 15.4 %) after recanalization therapy, and no use (NU, 50.4 %). The primary efficacy outcome was a 3-month modified Rankin Scale score of 0-1, and the secondary outcomes were neurologic improvement, neurologic deterioration and symptomatic hemorrhagic transformation during hospitalization. Results: Earlier use of statin was associated with a better primary outcome in a dose-response relationship (P for trend = 0.01) independent of premorbid statin use, stroke history, atrial fibrillation, stroke subtype, calendar year, and methods of recanalization therapy. The odds of a better primary outcome increased in D1 compared to NU (adjusted odds ratio, 2.96; 95 % confidence interval, 1.19-7.37). Earlier statin use was significantly associated with less neurologic deterioration and symptomatic hemorrhagic transformation in bivariate analyses but not in multivariable analyses. Interaction analysis revealed that the effect of early statin use was not altered by stroke subtype and recanalization modality (P for interaction = 0.97 and 0.26, respectively). Conclusion: Early statin use after recanalization therapy in ischemic stroke may improve the likelihood of a better functional outcome without increasing the risk of intracranial hemorrhage.

Original languageEnglish
Article number122
JournalBMC Neurology
Issue number1
Publication statusPublished - 2015
Externally publishedYes

Bibliographical note

Funding Information:
This study was partly supported by grants from the Korea Health 21 R&D project, Ministry of Health and Welfare, Korea (A102065).

Publisher Copyright:
© 2015 Kang et al.


  • Recanalization
  • Statin
  • Stenosis and occlusion
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology


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