Abstract
Non-steroidal anti-inflammatory drugs cause gastric ulceration through a number of mechanisms including inhibition of PG synthesis, generation of reactive oxygen species (ROS) and induction of apoptosis. Recently, matrix metalloproteinases (MMP) have been suggested to play a crucial role in these mechanisms. The present study investigated the protective effect of anthocyanins isolated from black rice bran (Heugjinjubyeo) against naproxen-induced gastric mucosal injury in rats. The oral administration of anthocyanins (5, 25 or 50mg/kg body weight) showed significant protection against naproxen (80mg/kg body weight)-induced gastric ulcer and inhibited lipid peroxidation in the gastric mucosa. In addition, pretreatment with anthocyanins resulted in a significant increase in the activities of radical-scavenging enzymes such as superoxide dismutase, catalase and glutathione peroxidase. Also biochemical and zymographic analyses suggested that the administration of anthocyanins gives a significant protection against naproxen-induced gastric antral ulcer through scavenging ROS and regulation of matrix metalloproteinase-2 (MMP-2) activity. The results of intracellular radical activation show that anthocyanins suppress the generation of intracellular ROS and attenuate the suppression of MMP-2 activity by naproxen. These results suggest that anthocyanins extracted from black rice may offer potential remedy of gastric antral ulceration.
Original language | English |
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Pages (from-to) | 1792-1801 |
Number of pages | 10 |
Journal | British Journal of Nutrition |
Volume | 106 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2011 Dec 28 |
Keywords
- Anthocyanins
- Gastric ulcers
- Matrix metalloproteinase
- Reactive oxygen species
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics