TY - JOUR
T1 - Effect of granulocyte colony-stimulating factor on chemotherapeutic activity of cytosine arabinoside in acute leukemic cell lines
AU - Cha, Kwang Eun
AU - Yoon, Soo Young
AU - Lee, Kap No
PY - 2001
Y1 - 2001
N2 - Recent studies have shown the presence of receptors for granulocyte colony-stimulating factor (G-CSF) on lymphoid leukemic cells. To determine the effect of G-CSF on chemotherapeutic activity of cytosine arabinoside (Ara-C) on lymphoid as well as myeloid leukemic cells, we evaluated cell counts, apoptosis, and growth inhibition in HL-60, KG-1, Molt-4, Jijoye, and CCRF-CEM cell lines after incubation with Ara-C (0.1 and 1 μmol/L) and/or 5 ng/mL G-CSF. G-CSF potentiated the effect of Ara-C on 2 of 3 lymphoid leukemic cell lines (Molt-4 and Jijoye), whereas it decreased the apoptosis and the effect of Ara-C on mveloid cell lines (HL-60 and KG-1).
AB - Recent studies have shown the presence of receptors for granulocyte colony-stimulating factor (G-CSF) on lymphoid leukemic cells. To determine the effect of G-CSF on chemotherapeutic activity of cytosine arabinoside (Ara-C) on lymphoid as well as myeloid leukemic cells, we evaluated cell counts, apoptosis, and growth inhibition in HL-60, KG-1, Molt-4, Jijoye, and CCRF-CEM cell lines after incubation with Ara-C (0.1 and 1 μmol/L) and/or 5 ng/mL G-CSF. G-CSF potentiated the effect of Ara-C on 2 of 3 lymphoid leukemic cell lines (Molt-4 and Jijoye), whereas it decreased the apoptosis and the effect of Ara-C on mveloid cell lines (HL-60 and KG-1).
KW - Apoptosis
KW - Cytosine arabinoside
KW - Granulocyte colony-stimulating factor
KW - Leukemic cell lines
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U2 - 10.1007/BF02981938
DO - 10.1007/BF02981938
M3 - Article
C2 - 11372732
AN - SCOPUS:0035260175
SN - 0925-5710
VL - 73
SP - 199
EP - 205
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 2
ER -