Effect of high intensity focused ultrasound (HIFU) in conjunction with a nanomedicines-microbubble complex for enhanced drug delivery

Hyounkoo Han, Hohyeon Lee, Kwangmeyung Kim, Hyuncheol Kim

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


Although nanomedicines have been intensively investigated for cancer therapy in the past, poor accumulation of nanomedicines in tumor sites remains a serious problem. Therefore, a novel drug delivery system is required to enhance accumulation and penetration of nanomedicines at the tumor site. Recently, high-intensity focused ultrasound (HIFU) has been highlighted as a non-invasive therapeutic modality, and showed enhanced therapeutic efficacy in combination with nanomedicines. Cavitation effect induced by the combination of HIFU and microbubbles results in transiently enhanced cell membrane permeability, facilitating improved drug delivery efficiency into tumor sites. Therefore, we introduce the acoustic cavitation and thermal/mechanical effects of HIFU in conjunction with microbubble to overcome the limitation of conventional drug delivery. The cavitation effect maximized by the strong acoustic energy of HIFU induced the preferential accumulation of nanomedicine locally released from the nanomedicines-microbubble complex in the tumor. In addition, the mechanical effect of HIFU allowed the accumulated nanomedicines to penetrate into deeper tumor region. The preferential accumulation and deeper penetration of nanomedicines by HIFU showed enhanced therapeutic efficacy, compared to low frequency ultrasound (US). These overall results demonstrate that the strategy combined nanomedicines-microbubble complex with HIFU is a promising tools for cancer therapy.

Original languageEnglish
Pages (from-to)75-86
Number of pages12
JournalJournal of Controlled Release
Publication statusPublished - 2017 Nov 28

Bibliographical note

Funding Information:
This work was supported by the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare (Grant Number: HI15C2797 ) and by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology ( NRF-2016R1A6A1A03012845 , and NRF-2017R1A2B2003194 ), Republic of Korea.

Publisher Copyright:
© 2017 Elsevier B.V.


  • Cavitation effect
  • High-intensity focused ultrasound
  • Human serum albumin
  • Microbubbles
  • Nanoparticle
  • Paclitaxel

ASJC Scopus subject areas

  • Pharmaceutical Science


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