Effect of Lactobacillus Fermentum as a Probiotic Agent on Bone Health in Postmenopausal Women

Hee Soo Han, Jung Geul Kim, Yoon Hyo Choi, Kyoung Min Lee, Tae Hun Kwon, Sae Hun Kim

Research output: Contribution to journalArticlepeer-review


Background: Probiotics are live microorganisms that confer health benefits on the host. Many animal studies have shown that among the probiotics, lactobacilli exert favorable effects on bone metabolism. Herein, we report the results of a randomized controlled trial performed to investigate the effect of Lactobacillus fermentum (L. fermentum) SRK414 on bone health in postmenopausal women. Methods: The bone turnover markers (BTMs) and bone mineral density (BMD) in participants in the study group (N= 27; mean age, 58.4±3.4 years) and control group (N = 26; mean age, 59.5±3.4 years) were compared during a 6-month trial. BTMs were measured at pretrial, 3 months post-trial, and 6 months post-trial, while BMD was measured at pre-trial and 6 months post-trial. Changes in the gut microorganisms were also evaluated. Results: Femur neck BMD showed a significant increase at 6 months post-trial in the study group (P= 0.030) but not in the control group. The control group showed a decrease in osteocalcin (OC) levels (P= 0.028), whereas the levels in the study group were maintained during the trial period. The change in L. fermentum concentration was significantly correlated with that in OC levels (r = 0.386, P= 0.047) in the study group at 3 months post-trial. Conclusions: Probiotic (L. fermentum SRK414) supplementation was found to maintain OC levels and increase femur neck BMD during a 6-month trial in postmenopausal women. Further studies with a larger number of participants and a longer study period are required to increase the utility of probiotics as an alternative to osteoporosis medication.

Original languageEnglish
Pages (from-to)225-233
Number of pages9
JournalJournal of Bone Metabolism
Issue number4
Publication statusPublished - 2022 Nov

Bibliographical note

Publisher Copyright:
Copyright © 2022 The Korean Society for Bone and Mineral Research.


  • Bone density
  • Osteocalcin
  • Osteoporosis
  • Probiotics
  • postmenopausal

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology


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