Effect of magnesium hydroxide nanoparticles with rod and plate shape on mechanical and biological properties of poly(L-lactide) composites

Chang Hun Kum; Seong Ho Seo; Sung Nam Kang; Bang Ju Park; Dong June Ahn; Yoon Ki Joung; Dong Keun Han

doi:10.1007/s13233-014-2140-8

Effect of magnesium hydroxide nanoparticles with rod and plate shape on mechanical and biological properties of poly(L-lactide) composites

Chang Hun Kum, Seong Ho Seo, Sung Nam Kang, Bang Ju Park, Dong June Ahn, Yoon Ki Joung, Dong Keun Han

Department of Chemical and Biological Engineering

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Two kinds of magnesium hydroxide (Mg(OH)₂) rods (Mg-Rod, 150 and 350 nm in size) and plates (Mg-PL, 60 and 300 nm) were prepared, and blended with poly(L-lactide) (PLLA) to obtain PLLA/Mg(OH)₂ composites to investigate the effect of the shape and size of Mg(OH)₂ particles. The structure, morphology, pH change, thermal and mechanical properties, cytotoxicity, and inflammation of Mg(OH)₂ control and PLLA/Mg(OH)₂ composites were evaluated. PLLA/Mg-Rod150 (30%) composite showed a 50% higher tensile strength and a 45% improved modulus as compared with PLLA/Mg-PL300 30% composite. Although Mg-Rods displayed similar cell viability (above 80%) as compared to Mg-PLs, the expression levels of TNF-α from Mg-PL60 gradually increased with increasing concentrations from 1 to 300 μg. This indicates that Mg-PL60 had a potential cytotoxicity due to endocytosis. In addition, the byproduct of PLLA/Mg-Rods composite was more effectively neutralized than that of the PLLA/Mg-PLs composite, but cell viability and the expression levels of TNF-α were similar. Therefore, the use of our PLLA/Mg-Rod composite system would be a promising strategy to prevent the current fatal problems in biomedical applications including biodegradable implants such as stents.

Original language	English
Pages (from-to)	1032-1041
Number of pages	10
Journal	Macromolecular Research
Volume	22
Issue number	9
DOIs	https://doi.org/10.1007/s13233-014-2140-8
Publication status	Published - 2014 Sept 20

Bibliographical note

Publisher Copyright:
© 2014, The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht.

Keywords

inflammation
magnesium hydroxide
mechanical property
poly(L-lactide)
shape

ASJC Scopus subject areas

Chemical Engineering(all)
Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1007/s13233-014-2140-8

Cite this

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title = "Effect of magnesium hydroxide nanoparticles with rod and plate shape on mechanical and biological properties of poly(L-lactide) composites",

abstract = "Two kinds of magnesium hydroxide (Mg(OH)2) rods (Mg-Rod, 150 and 350 nm in size) and plates (Mg-PL, 60 and 300 nm) were prepared, and blended with poly(L-lactide) (PLLA) to obtain PLLA/Mg(OH)2 composites to investigate the effect of the shape and size of Mg(OH)2 particles. The structure, morphology, pH change, thermal and mechanical properties, cytotoxicity, and inflammation of Mg(OH)2 control and PLLA/Mg(OH)2 composites were evaluated. PLLA/Mg-Rod150 (30%) composite showed a 50% higher tensile strength and a 45% improved modulus as compared with PLLA/Mg-PL300 30% composite. Although Mg-Rods displayed similar cell viability (above 80%) as compared to Mg-PLs, the expression levels of TNF-α from Mg-PL60 gradually increased with increasing concentrations from 1 to 300 μg. This indicates that Mg-PL60 had a potential cytotoxicity due to endocytosis. In addition, the byproduct of PLLA/Mg-Rods composite was more effectively neutralized than that of the PLLA/Mg-PLs composite, but cell viability and the expression levels of TNF-α were similar. Therefore, the use of our PLLA/Mg-Rod composite system would be a promising strategy to prevent the current fatal problems in biomedical applications including biodegradable implants such as stents.",

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author = "Kum, {Chang Hun} and Seo, {Seong Ho} and Kang, {Sung Nam} and Park, {Bang Ju} and Ahn, {Dong June} and Joung, {Yoon Ki} and Han, {Dong Keun}",

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AU - Kum, Chang Hun

AU - Seo, Seong Ho

AU - Kang, Sung Nam

AU - Park, Bang Ju

AU - Ahn, Dong June

AU - Joung, Yoon Ki

AU - Han, Dong Keun

PY - 2014/9/20

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N2 - Two kinds of magnesium hydroxide (Mg(OH)2) rods (Mg-Rod, 150 and 350 nm in size) and plates (Mg-PL, 60 and 300 nm) were prepared, and blended with poly(L-lactide) (PLLA) to obtain PLLA/Mg(OH)2 composites to investigate the effect of the shape and size of Mg(OH)2 particles. The structure, morphology, pH change, thermal and mechanical properties, cytotoxicity, and inflammation of Mg(OH)2 control and PLLA/Mg(OH)2 composites were evaluated. PLLA/Mg-Rod150 (30%) composite showed a 50% higher tensile strength and a 45% improved modulus as compared with PLLA/Mg-PL300 30% composite. Although Mg-Rods displayed similar cell viability (above 80%) as compared to Mg-PLs, the expression levels of TNF-α from Mg-PL60 gradually increased with increasing concentrations from 1 to 300 μg. This indicates that Mg-PL60 had a potential cytotoxicity due to endocytosis. In addition, the byproduct of PLLA/Mg-Rods composite was more effectively neutralized than that of the PLLA/Mg-PLs composite, but cell viability and the expression levels of TNF-α were similar. Therefore, the use of our PLLA/Mg-Rod composite system would be a promising strategy to prevent the current fatal problems in biomedical applications including biodegradable implants such as stents.

AB - Two kinds of magnesium hydroxide (Mg(OH)2) rods (Mg-Rod, 150 and 350 nm in size) and plates (Mg-PL, 60 and 300 nm) were prepared, and blended with poly(L-lactide) (PLLA) to obtain PLLA/Mg(OH)2 composites to investigate the effect of the shape and size of Mg(OH)2 particles. The structure, morphology, pH change, thermal and mechanical properties, cytotoxicity, and inflammation of Mg(OH)2 control and PLLA/Mg(OH)2 composites were evaluated. PLLA/Mg-Rod150 (30%) composite showed a 50% higher tensile strength and a 45% improved modulus as compared with PLLA/Mg-PL300 30% composite. Although Mg-Rods displayed similar cell viability (above 80%) as compared to Mg-PLs, the expression levels of TNF-α from Mg-PL60 gradually increased with increasing concentrations from 1 to 300 μg. This indicates that Mg-PL60 had a potential cytotoxicity due to endocytosis. In addition, the byproduct of PLLA/Mg-Rods composite was more effectively neutralized than that of the PLLA/Mg-PLs composite, but cell viability and the expression levels of TNF-α were similar. Therefore, the use of our PLLA/Mg-Rod composite system would be a promising strategy to prevent the current fatal problems in biomedical applications including biodegradable implants such as stents.

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KW - magnesium hydroxide

KW - mechanical property

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Effect of magnesium hydroxide nanoparticles with rod and plate shape on mechanical and biological properties of poly(L-lactide) composites

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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