Effect of magnetic modulation of mitochondrial voltage-dependent anion channel 2 against beta-amyloid induced neurotoxicity

Sujin Lee; Junghoon Lee; Sang Jun Sim; Misun Cha

doi:10.1039/c4ra10755a

Effect of magnetic modulation of mitochondrial voltage-dependent anion channel 2 against beta-amyloid induced neurotoxicity

Sujin Lee, Junghoon Lee, Sang Jun Sim, Misun Cha

Department of Chemical and Biological Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

The magnetic capture of mitochondrial VDAC2 with bacterial magnetic particles (BMPs) conjugated VDAC2 antibody (BMPs-Ab) significantly decreased the expressed intracellular calcium levels and neurotoxicity induced by Aβ. This magnetic modulation of mitochondrial VDAC, playing a key role in various Ca²⁺ flux pathways, should provide attractive targets for the future development of AD treatments.

Original language	English
Pages (from-to)	63681-63684
Number of pages	4
Journal	RSC Advances
Volume	4
Issue number	109
DOIs	https://doi.org/10.1039/c4ra10755a
Publication status	Published - 2014

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

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10.1039/c4ra10755a

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title = "Effect of magnetic modulation of mitochondrial voltage-dependent anion channel 2 against beta-amyloid induced neurotoxicity",

abstract = "The magnetic capture of mitochondrial VDAC2 with bacterial magnetic particles (BMPs) conjugated VDAC2 antibody (BMPs-Ab) significantly decreased the expressed intracellular calcium levels and neurotoxicity induced by Aβ. This magnetic modulation of mitochondrial VDAC, playing a key role in various Ca2+ flux pathways, should provide attractive targets for the future development of AD treatments.",

author = "Sujin Lee and Junghoon Lee and Sim, {Sang Jun} and Misun Cha",

note = "Publisher Copyright: {\textcopyright} 2014 The Royal Society of Chemistry.",

year = "2014",

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AU - Lee, Sujin

AU - Lee, Junghoon

AU - Sim, Sang Jun

AU - Cha, Misun

PY - 2014

Y1 - 2014

N2 - The magnetic capture of mitochondrial VDAC2 with bacterial magnetic particles (BMPs) conjugated VDAC2 antibody (BMPs-Ab) significantly decreased the expressed intracellular calcium levels and neurotoxicity induced by Aβ. This magnetic modulation of mitochondrial VDAC, playing a key role in various Ca2+ flux pathways, should provide attractive targets for the future development of AD treatments.

AB - The magnetic capture of mitochondrial VDAC2 with bacterial magnetic particles (BMPs) conjugated VDAC2 antibody (BMPs-Ab) significantly decreased the expressed intracellular calcium levels and neurotoxicity induced by Aβ. This magnetic modulation of mitochondrial VDAC, playing a key role in various Ca2+ flux pathways, should provide attractive targets for the future development of AD treatments.

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U2 - 10.1039/c4ra10755a

DO - 10.1039/c4ra10755a

M3 - Article

AN - SCOPUS:84937022102

SN - 2046-2069

VL - 4

SP - 63681

EP - 63684

JO - RSC Advances

JF - RSC Advances

IS - 109

ER -

Effect of magnetic modulation of mitochondrial voltage-dependent anion channel 2 against beta-amyloid induced neurotoxicity

Abstract

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