Effect of microencapsulated precipitants of lactobacillus casei ATCC 393 on helicobacter pylori eradication

J. A. Ko, H. J. Lim, H. J. Park

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Precipitants of Lactobacillus casei ATCC 393-loaded chitosan microspheres were prepared by electrostatic interaction between chitosan (CS) and poly-γ-glutamic acid (γ-PGA). The loading efficiency was approximately 80%, and the zeta potential of the microspheres became more positively charged as the molar ratio of the chitosan amino group was increased. The particles were confirmed to have a spherical shape by optical microscopy. A release test using simulated gastric fluid (SGF) was also performed. The results show that the precipitants were gradually released from the CS-γ-PGA microspheres at a rate of almost 80% after 60 min. Both the inhibition of Helicobacter pylori growth and the anti-adhesive activity of encapsulated precipitants were maintained after exposure to SGF. These results indicate that CS-γ-PGA microspheres may provide a delivery system for the effective eradication of H. pylori.

Original languageEnglish
Pages (from-to)631-635
Number of pages5
JournalProcess Biochemistry
Issue number3
Publication statusPublished - 2011 Mar

Bibliographical note

Funding Information:
This study was supported by a Grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea ( A050376 ).


  • Chitosan
  • Helicobacter pylori
  • Lactobacillus casei ATCC 393
  • Microspheres
  • Poly-γ-glutamic

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology


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