Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells

Ki Yong Lee; Lim Hwang; Eun Ju Jeong; Seung Hyun Kim; Young Choong Kim; Sang Hyun Sung

doi:10.1271/bbb.100200

Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells

Ki Yong Lee
, Lim Hwang
, Eun Ju Jeong
, Seung Hyun Kim
, Young Choong Kim
, Sang Hyun Sung

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

A methanolic extract of Agrimonia eupatoria (Rosaceae) significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. A new flavonoid, characterized as kaempferol 3-O-β-D-(2″-O-acetyl- 6″-(E)-p-coumaroyl)-glucopyranoside (2″-acetyltiliroside (1), was isolated from the methanolic extract of A. eupatoria stems together with nine known flavonoids. Compounds 4, 7, 8 and 9 all showed a neuroprotective effect on glutamate-induced toxicity in HT22 cells.

Original language	English
Pages (from-to)	1704-1706
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	74
Issue number	8
DOIs	https://doi.org/10.1271/bbb.100200
Publication status	Published - 2010
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1271/bbb.100200

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title = "Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells",

abstract = "A methanolic extract of Agrimonia eupatoria (Rosaceae) significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. A new flavonoid, characterized as kaempferol 3-O-β-D-(2″-O-acetyl- 6″-(E)-p-coumaroyl)-glucopyranoside (2″-acetyltiliroside (1), was isolated from the methanolic extract of A. eupatoria stems together with nine known flavonoids. Compounds 4, 7, 8 and 9 all showed a neuroprotective effect on glutamate-induced toxicity in HT22 cells.",

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AU - Lee, Ki Yong

AU - Hwang, Lim

AU - Jeong, Eun Ju

AU - Kim, Seung Hyun

AU - Kim, Young Choong

AU - Sung, Sang Hyun

PY - 2010

Y1 - 2010

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AB - A methanolic extract of Agrimonia eupatoria (Rosaceae) significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. A new flavonoid, characterized as kaempferol 3-O-β-D-(2″-O-acetyl- 6″-(E)-p-coumaroyl)-glucopyranoside (2″-acetyltiliroside (1), was isolated from the methanolic extract of A. eupatoria stems together with nine known flavonoids. Compounds 4, 7, 8 and 9 all showed a neuroprotective effect on glutamate-induced toxicity in HT22 cells.

UR - https://www.scopus.com/pages/publications/77956027401

U2 - 10.1271/bbb.100200

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AN - SCOPUS:77956027401

SN - 0916-8451

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JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 8

ER -

Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells

Abstract

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