TY - JOUR
T1 - Effect of normobaric hyperoxic therapy on tissue oxygenation in diabetic feet
T2 - A pilot study
AU - Moon, Kyung Chul
AU - Han, Seung-Kyu
AU - Lee, Ye Na
AU - Jeong, Seong-Ho
AU - Dhong, Eun-Sang
AU - Kim, Woo-Kyung
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Adequate tissue oxygenation is an essential factor in diabetic foot management. Hyperbaric oxygen (HBO) therapy has been successfully used as adjunctive treatment to improve the healing of diabetic foot ulcers. However, the clinical uses of HBO therapy are limited due to the low availability of HBO chambers, poor patient compliance, and high oxidative potential. Normobaric hyperoxic (NBO) therapy may be a potentially attractive alternative to HBO therapy because of its high availability, good patient compliance, and few technical requirements. Several studies on NBO therapy to attenuate infarct volume after stroke have provided compelling evidence. However, there have been no reports regarding the effect of NBO therapy in the field of wound healing. The purpose of this study was to evaluate the effect of NBO therapy on tissue oxygenation of diabetic feet. This study included 100 patients with diabetic foot ulcers (64 males and 36 females). Transcutaneous partial oxygen tension (TcPO2) values of diabetic feet were measured before, during, and after NBO therapy. The mean TcPO2 values before, during, and after therapy were 46.6 ± 21.5, 88.9 ± 48.0, and 49.9 ± 23.8 mmHg (p < 0.001), respectively. The lower the initial TcPO2 level, the more TcPO2 increased. The results reveal that NBO therapy significantly increases the tissue oxygenation level of diabetic feet.
AB - Adequate tissue oxygenation is an essential factor in diabetic foot management. Hyperbaric oxygen (HBO) therapy has been successfully used as adjunctive treatment to improve the healing of diabetic foot ulcers. However, the clinical uses of HBO therapy are limited due to the low availability of HBO chambers, poor patient compliance, and high oxidative potential. Normobaric hyperoxic (NBO) therapy may be a potentially attractive alternative to HBO therapy because of its high availability, good patient compliance, and few technical requirements. Several studies on NBO therapy to attenuate infarct volume after stroke have provided compelling evidence. However, there have been no reports regarding the effect of NBO therapy in the field of wound healing. The purpose of this study was to evaluate the effect of NBO therapy on tissue oxygenation of diabetic feet. This study included 100 patients with diabetic foot ulcers (64 males and 36 females). Transcutaneous partial oxygen tension (TcPO2) values of diabetic feet were measured before, during, and after NBO therapy. The mean TcPO2 values before, during, and after therapy were 46.6 ± 21.5, 88.9 ± 48.0, and 49.9 ± 23.8 mmHg (p < 0.001), respectively. The lower the initial TcPO2 level, the more TcPO2 increased. The results reveal that NBO therapy significantly increases the tissue oxygenation level of diabetic feet.
KW - Diabetic foot
KW - Oxygen therapy
KW - Tissue oxygenation
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=84908235673&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908235673&partnerID=8YFLogxK
U2 - 10.1016/j.bjps.2014.07.010
DO - 10.1016/j.bjps.2014.07.010
M3 - Article
C2 - 25086687
AN - SCOPUS:84908235673
SN - 1748-6815
VL - 67
SP - 1580
EP - 1586
JO - Journal of Plastic, Reconstructive and Aesthetic Surgery
JF - Journal of Plastic, Reconstructive and Aesthetic Surgery
IS - 11
ER -
