Effect of Pitavastatin Compared with Atorvastatin and Rosuvastatin on New-Onset Diabetes Mellitus in Patients With Acute Myocardial Infarction

KAMIR-NIH Investigators

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Although statin use in patients with acute myocardial infarction (AMI) is mandatory, it has been suggested to be associated with new-onset diabetes mellitus (NODM). In real world practice, moderate-intensity statin therapy is more commonly used than high-intensity statin therapy. In this study, we investigated the impact of moderate-intensity pitavastatin (2 to 4 mg) compared with moderate-intensity atorvastatin (10 to 20 mg) and rosuvastatin (5 to 10 mg) on the development of NODM during a follow-up period of up to 3 years. Between November 2011 and May 2015, 2001 patients with AMI who did not have diabetes mellitus were investigated. The cumulative incidence of NODM was evaluated in all groups. To adjust for potential confounders, multinomial propensity scores were used. Cox proportional hazard models were used to assess the hazard ratio of NODM in the atorvastatin and rosuvastatin groups compared with pitavastatin group. The cumulative incidence of NODM was significantly lower in pitavastatin group compared with the atorvastatin and rosuvastatin groups (3.0% vs 8.4% vs 10.4%, respectively; Log-rank p value = 0.001). After weighting the baseline characteristics of the 3 statin groups by multinomial propensity scores, atorvastatin (hazard ratio: 2.615, 95% confidence interval: 1.163 to 5.879) and rosuvastatin (hazard ratio: 3.906, 95% confidence interval: 1.756 to 8.688) were found to be associated with a higher incidence of NODM compared with pitavastatin therapy on multivariable analysis. Moderate-intensity pitavastatin therapy is associated with a lower incidence of NODM in patients with AMI and has similar clinical outcomes to moderate-intensity atorvastatin and rosuvastatin therapy.

Original languageEnglish
Pages (from-to)922-928
Number of pages7
JournalAmerican Journal of Cardiology
Volume122
Issue number6
DOIs
Publication statusPublished - 2018 Sept 15

Bibliographical note

Funding Information:
This study was done with the support of Korean Circulation Society (KCS). The KAMIR study group of the KSC was as follows: Woong Chol Kang, Gachon University Gil Medical Center, Incheon; Kiyuk Chang, Catholic University Hospital, Seoul; Seung Ho Hur, Keimyung University Dongsan Medical Center, Daegu; Seung Woon Rha, Korea University Guro Hospital, Seoul; Kwang-Soo Cha, Pusan National University Hospital, Busan; Hyeon Cheol Gwon, Samsung Medical Center, Seoul; Seok Kyu Oh, Wonkwang University Hospital, Iksan; Jei Keon Chae, Chonbuk National University Hospital, Jeonju; Kyung-Kook Hwang, Chungbuk National University Hospital, Chungju; Chong Jin Kim, East West Neo Medical Center, Seoul; Jung Han Yoon, Wonju Severance Christian Hospital, Wonju; Jin Yong Hwang, Gyeongsang National University Hospital, Jinju; Doo Il Kim, Inje University Busan Paik Hospital, Busan; Seung Jae Joo, Jeju National University Hospital, Jeju.

Publisher Copyright:
© 2018 Elsevier Inc.

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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