Effect of PPAR-δ agonist on the expression of visfatin, adiponectin, and resistin in rat adipose tissue and 3T3-L1 adipocytes

K. C. Choi, S. Y. Lee, H. J. Yoo, O. H. Ryu, K. W. Lee, S. M. Kim, S. H. Baik, K. M. Choi

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38 Citations (Scopus)


It has been recently reported that activation of PPAR-δ, by specific agonists or genetic manipulation, alleviates dyslipidemia, hyperglycemia, and insulin resistance in animal models of obesity and type 2 diabetes. The purpose of the present study was to determine whether the PPAR-δ agonist has a direct effect on adipokines in visceral adipose tissue of rats and in cultured adipocytes. We examined the expression of visfatin, adiponectin, and resistin mRNA in visceral adipose tissue of Wistar rats fed a high-fat diet and 3T3-L1 adipocytes treated with PPAR-δ agonist (L-165041). Body weight and biochemical measurements were performed. Rats fed a high-fat diet showed a greater increase in body weight than those fed a standard diet (P < 0.05), and treatment with L-165041 (10 mg/kg/day) significantly decreased weight gain (P < 0.05). The concentration of total cholesterol was lower, and HDL cholesterol was higher in L-165041-treated rats (P < 0.05). In the visceral adipose tissue of L-165041-treated rats, visfatin and adiponectin mRNA levels significantly increased compared to those of the untreated rats (P < 0.05). However, the expression of resistin decreased in the L-165041-treated rats. Furthermore, in cultured 3T3-L1 adipocytes, the level of visfatin and adiponectin mRNA was up-regulated in response to L-165041 treatment for nine days. By contrast, resistin mRNA levels were down-regulated by L-165041 treatment. The present study provides a novel evidence to suggest that the PPAR-δ agonist has regulatory effects on a variety of adipokines, and these effects might explain some of their metabolic function.

Original languageEnglish
Pages (from-to)62-67
Number of pages6
JournalBiochemical and biophysical research communications
Issue number1
Publication statusPublished - 2007 May 25

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Research Foundation (KRF-2005-003-E00110) and a grant of the Korean Health 21 R&D Project (A 050463), Ministry of Health & Welfare, Republic of Korea.


  • Adipokine
  • Adiponectin
  • Metabolic syndrome
  • Peroxisome proliferator-activated receptor delta
  • Resistin
  • Visfatin

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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