Effect of processing method on platycodin D content in Platycodon grandiflorum roots

Jaeyoung Kwon, Hyaemin Lee, Nahyun Kim, Je Hyun Lee, Mi Hee Woo, Jinwoong Kim, Yeong Shik Kim, Dongho Lee

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Platycodon grandiflorum root is a traditional medicine and food material rich in triterpenoid saponins. Its major constituent, platycodin D (PD), is known to have various pharmacological properties, but processing methods may influence the PD content. In this study, a fully validated HPLC–ELSD method was developed for the quantification of PD in various states of 73 P. grandiflorum root samples from East Asia, and it exhibited a marked variation of the content. Furthermore, the effects of processing procedures such as peeling and drying temperature on the PD content were investigated using UPLC–ELSD analysis, and as a result, a significant influence of processing methods such as peeling and heating of samples on the content was confirmed. Specifically, unpeeled samples that were dried at 40 °C showed the greatest PD content. The obtained results could facilitate the reliable standardization of P. grandiflorum for precise authentication and efficacious applications.

Original languageEnglish
Pages (from-to)1087-1093
Number of pages7
JournalArchives of pharmacal research
Issue number9
Publication statusPublished - 2017 Sept 1


  • Platycodi Radix
  • Platycodin D
  • Platycodon grandiflorum
  • Processing method

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry


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