Effect of processing method on platycodin D content in Platycodon grandiflorum roots

Jaeyoung Kwon; Hyaemin Lee; Nahyun Kim; Je Hyun Lee; Mi Hee Woo; Jinwoong Kim; Yeong Shik Kim; Dongho Lee

doi:10.1007/s12272-017-0946-6

Effect of processing method on platycodin D content in Platycodon grandiflorum roots

Jaeyoung Kwon, Hyaemin Lee, Nahyun Kim, Je Hyun Lee, Mi Hee Woo, Jinwoong Kim, Yeong Shik Kim, Dongho Lee

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Platycodon grandiflorum root is a traditional medicine and food material rich in triterpenoid saponins. Its major constituent, platycodin D (PD), is known to have various pharmacological properties, but processing methods may influence the PD content. In this study, a fully validated HPLC–ELSD method was developed for the quantification of PD in various states of 73 P. grandiflorum root samples from East Asia, and it exhibited a marked variation of the content. Furthermore, the effects of processing procedures such as peeling and drying temperature on the PD content were investigated using UPLC–ELSD analysis, and as a result, a significant influence of processing methods such as peeling and heating of samples on the content was confirmed. Specifically, unpeeled samples that were dried at 40 °C showed the greatest PD content. The obtained results could facilitate the reliable standardization of P. grandiflorum for precise authentication and efficacious applications.

Original language	English
Pages (from-to)	1087-1093
Number of pages	7
Journal	Archives of pharmacal research
Volume	40
Issue number	9
DOIs	https://doi.org/10.1007/s12272-017-0946-6
Publication status	Published - 2017 Sept 1

Bibliographical note

Funding Information:
Acknowledgements This work was supported by a grant from the National Research Foundation of Korea (NRF-2015R1D1A1A01060 321).

Publisher Copyright:
© 2017, The Pharmaceutical Society of Korea.

Keywords

HPLC–ELSD
Platycodi Radix
Platycodin D
Platycodon grandiflorum
Processing method

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/s12272-017-0946-6

Cite this

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title = "Effect of processing method on platycodin D content in Platycodon grandiflorum roots",

abstract = "Platycodon grandiflorum root is a traditional medicine and food material rich in triterpenoid saponins. Its major constituent, platycodin D (PD), is known to have various pharmacological properties, but processing methods may influence the PD content. In this study, a fully validated HPLC–ELSD method was developed for the quantification of PD in various states of 73 P. grandiflorum root samples from East Asia, and it exhibited a marked variation of the content. Furthermore, the effects of processing procedures such as peeling and drying temperature on the PD content were investigated using UPLC–ELSD analysis, and as a result, a significant influence of processing methods such as peeling and heating of samples on the content was confirmed. Specifically, unpeeled samples that were dried at 40 °C showed the greatest PD content. The obtained results could facilitate the reliable standardization of P. grandiflorum for precise authentication and efficacious applications.",

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author = "Jaeyoung Kwon and Hyaemin Lee and Nahyun Kim and Lee, {Je Hyun} and Woo, {Mi Hee} and Jinwoong Kim and Kim, {Yeong Shik} and Dongho Lee",

note = "Funding Information: Acknowledgements This work was supported by a grant from the National Research Foundation of Korea (NRF-2015R1D1A1A01060 321). Publisher Copyright: {\textcopyright} 2017, The Pharmaceutical Society of Korea.",

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AU - Woo, Mi Hee

AU - Kim, Jinwoong

AU - Kim, Yeong Shik

AU - Lee, Dongho

N1 - Funding Information: Acknowledgements This work was supported by a grant from the National Research Foundation of Korea (NRF-2015R1D1A1A01060 321). Publisher Copyright: © 2017, The Pharmaceutical Society of Korea.

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N2 - Platycodon grandiflorum root is a traditional medicine and food material rich in triterpenoid saponins. Its major constituent, platycodin D (PD), is known to have various pharmacological properties, but processing methods may influence the PD content. In this study, a fully validated HPLC–ELSD method was developed for the quantification of PD in various states of 73 P. grandiflorum root samples from East Asia, and it exhibited a marked variation of the content. Furthermore, the effects of processing procedures such as peeling and drying temperature on the PD content were investigated using UPLC–ELSD analysis, and as a result, a significant influence of processing methods such as peeling and heating of samples on the content was confirmed. Specifically, unpeeled samples that were dried at 40 °C showed the greatest PD content. The obtained results could facilitate the reliable standardization of P. grandiflorum for precise authentication and efficacious applications.

AB - Platycodon grandiflorum root is a traditional medicine and food material rich in triterpenoid saponins. Its major constituent, platycodin D (PD), is known to have various pharmacological properties, but processing methods may influence the PD content. In this study, a fully validated HPLC–ELSD method was developed for the quantification of PD in various states of 73 P. grandiflorum root samples from East Asia, and it exhibited a marked variation of the content. Furthermore, the effects of processing procedures such as peeling and drying temperature on the PD content were investigated using UPLC–ELSD analysis, and as a result, a significant influence of processing methods such as peeling and heating of samples on the content was confirmed. Specifically, unpeeled samples that were dried at 40 °C showed the greatest PD content. The obtained results could facilitate the reliable standardization of P. grandiflorum for precise authentication and efficacious applications.

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Effect of processing method on platycodin D content in Platycodon grandiflorum roots

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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