Abstract
Platycodon grandiflorum root is a traditional medicine and food material rich in triterpenoid saponins. Its major constituent, platycodin D (PD), is known to have various pharmacological properties, but processing methods may influence the PD content. In this study, a fully validated HPLC–ELSD method was developed for the quantification of PD in various states of 73 P. grandiflorum root samples from East Asia, and it exhibited a marked variation of the content. Furthermore, the effects of processing procedures such as peeling and drying temperature on the PD content were investigated using UPLC–ELSD analysis, and as a result, a significant influence of processing methods such as peeling and heating of samples on the content was confirmed. Specifically, unpeeled samples that were dried at 40 °C showed the greatest PD content. The obtained results could facilitate the reliable standardization of P. grandiflorum for precise authentication and efficacious applications.
| Original language | English |
|---|---|
| Pages (from-to) | 1087-1093 |
| Number of pages | 7 |
| Journal | Archives of pharmacal research |
| Volume | 40 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2017 Sept 1 |
Bibliographical note
Publisher Copyright:© 2017, The Pharmaceutical Society of Korea.
Keywords
- HPLC–ELSD
- Platycodi Radix
- Platycodin D
- Platycodon grandiflorum
- Processing method
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
- Organic Chemistry