Effect of quercetin-rich onion peel extracts on arterial thrombosis in rats

Seung Min Lee, Jiyoung Moon, Ji Hyung Chung, Yong Jun Cha, Min Jeong Shin

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


The aim of this study was to examine whether oral supplementation of quercetin-rich onion peel extract (OPE) influences blood coagulation and arterial thrombosis in Sprague-Dawley (SD) rats. 24 male rats, 5. weeks old, were divided into three groups with different diets (C: control, 2. mg OPE: chow diet with 2. mg OPE supplementation, 10. mg OPE: chow diet with 10. mg OPE supplementation) for 6. weeks. Blood coagulation parameters including prothrombin time (PT), activated partial thromboplastin time (aPTT) and platelet aggregation were examined. The OPE did not affect blood cholesterol levels but significantly decreased blood triglyceride and glucose levels. PT, aPTT and platelet aggregation were not significantly different among all tested groups. However, in vivo arterial thrombosis was significantly delayed in groups that were fed 2. mg and 10. mg OPE diets compared to the control group. In addition, the OPE greatly diminished thrombin-induced expression of tissue factor in human umbilical vein endothelial cells (HUVECs), a coagulation initiator. In addition, extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling pathways activated by thrombin treatment were prevented by the OPE pre-treatment. These results indicate that OPE may have anti-thrombotic effects through restricting the induced expression of tissue factor via down-regulating mitogen-activated protein kinase (MAPK) activation upon coagulation stimulus, leading to the prolongation of time for arterial thrombosis.

Original languageEnglish
Pages (from-to)99-105
Number of pages7
JournalFood and Chemical Toxicology
Publication statusPublished - 2013 Jul

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012-0002119) and High Value-added Food Technology Development Program, Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea.


  • APTT
  • Arterial thrombosis
  • Blood coagulation
  • Onion peel extract
  • Quercetin

ASJC Scopus subject areas

  • Food Science
  • Toxicology


Dive into the research topics of 'Effect of quercetin-rich onion peel extracts on arterial thrombosis in rats'. Together they form a unique fingerprint.

Cite this